Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT06806410

The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery

Patients undergoing hand, wrist, and elbow surgery may experience pain after surgery. The orthopedic surgeon may provide prescription pain medications after surgery to assist with pain control. However, with concern of the opioid epidemic, many patients would rather minimize the use of narcotic pain prescriptions after having surgery. As an alternative, ultrasound guided regional nerve blocks can assist with postoperative pain control.

patients consented to this study will be randomized into three groups: 1) will receive an ultrasound guided nerve block with local anesthesia only, 2) will receive an ultrasound guided nerve block with local anesthesia and a steroid dexamethasone, 3) will receive an ultrasound guided nerve block with liposomal bupivacaine.

our study team will make phone calls after surgery to the patient to determine how long the block lasted for, and how many opioid pain pills were taken up to 3 days after surgery.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Notify Me

Key information

Conditions

Hand Surgery Arm Injuries Connective Tissue Diseases Contracture Distal Radius Fracture Dupuytren Contracture Elbow Surgery Fibroma Finger Fracture Fracture Fixation Fractures, Bone Muscular Diseases Musculoskeletal Diseases Neoplasms Neoplasms by Histologic Type Neoplasms, Connective Tissue Neoplasms, Connective and Soft Tissue Neoplasms, Fibrous Tissue Skin and Connective Tissue Diseases Wounds and Injuries Wrist Arthropathy Wrist Fractures Wrist Injuries Wrist Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

St. Luke's University Health Network

Bethlehem, Pennsylvania, 18015, United States

About this study

Our study team predicts that the ultrasound guided nerve block with liposomal bupivacaine can last approximately 48 hours, while the block with local anesthesia and dexamethasone will last approximately 30 hours, and the block with local anesthesia only may last up to 24 hours

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients scheduled to undergo finger, hand, wrist, elbow surgery with a hand surgeon at St. Luke's University Hospital in Bethlehem, Pennsylvania
  • patients greater than 18 years of age, able to provide written consent for surgery and study

Exclusion criteria

  • patients that cannot provide written consent for finger, hand, wrist, elbow surgery
  • patients with known allergies to local anesthetics
  • patients with severe liver disease
  • patients with a condition known as methemoglobinemia

Treatment and study plan

Liposomal bupivacaine (LB)

Drug

our study team wishes to determine effect of liposomal bupivacaine in regional nerve blocks for surgery of the upper extremity (finger, hand, wrist, elbow)

Other names: liposomal bupivacaine, exparel

Dexamethasone

Drug

dexamethasone injected in perineural area can extend the regional nerve block

Other names: decadron perineural injection

Primary outcomes

  1. Subjective length of duration of block

    Time frame: feedback obtained up until day 3 after surgery

    our study team contacts the patients 4 days after surgery to ask how long their regional nerve block lasted

Secondary outcomes

  1. Number of opioid pills taken until postoperative day 3

    Time frame: feedback until day 3 after surgery

    our study team contacts the patients to ask how many opioid pain pills were taken from arrival to home up until postoperative day 3

Sponsors and collaborators

Lead sponsor

St. Luke's Hospital, Pennsylvania

Other

Registry information

Official study title

The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery: a Prospective, Randomized, Blinded Controlled Trial

Important dates

Study start
2023
Primary completion
2024
Study completion
2025
First posted
Feb 4, 2025
Registry last updated
Feb 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.