The Effects of Dexamethasone and Ibuprofen on Postoperative Analgesia in Patients Undergoing Hand and Forearm Surgery With Axillary Brachial Plexus Block

This study aims to comparatively examine the effects of preemptive intravenous dexamethasone and intravenous ibuprofen use on the duration of analgesia in ultrasound-guided Axillary Brachial Plexus Block applications for patients undergoing hand and forearm surgery. Furthermore, investigating the relationship between the study drugs and the incidence of Postoperative Nausea and Vomiting and determining the time until the first use of rescue analgesic are also among the secondary objectives.

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Key information

Conditions

Axillary Block Dexamethasone Forearm Surgery Hand Surgery Ibuprofen Postoperative Analgesia

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Prof. Dr. Cemil Tascioglu City Hospital

Istanbul, 34384, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient's consent to participate in the study (Informed consent)
Aged between 18 and 65 years
ASA physical status I or II
Being oriented and cooperative
Scheduled to undergo hand or forearm surgery
Body Mass Index (BMI) below 40 kg/m²
Scheduled for axillary brachial plexus blockade

Exclusion criteria

Patient's refusal to participate in the study
Refusal of regional anesthesia
Known allergy to local anesthetics
Known allergy to ibuprofen
Known allergy to dexamethasone
Presence of coagulopathy
Local infection at the site of regional anesthesia application
Presence of malignancy at the surgical site
Diagnosis of diabetes mellitus
Body Mass Index (BMI) of 40 kg/m² or above
Duration of surgery exceeding 4 hours
Administration of opioid medication during the preoperative or intraoperative period

Treatment and study plan

IV Dexamethasone 8mg

Drug

Patients who are in group D had intravenouse 8 mg dexamethasone before axillary brachial plexus blockade.

IV ibuprofen

Drug

Patients who are in group I had intravenouse 400 mg ibuprofen before axillary brachial plexus blockade.

Primary outcomes

Duration of analgesia

Time frame: 24 hours

Duration of analgesia was defined as the time from the performance of the block until the patient's first report of pain.

Secondary outcomes

Incidence of PONV

Time frame: 24 hours

The incidence of PONV during the first 24 hours following the block administration will be evaluated.

Sponsors and collaborators

Lead sponsor

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Apr 15, 2026
Registry last updated: May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed