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Completed

NCT Number: NCT02754089

The Effects of Rhus Coriaria L. on Body Weight

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as "Somagh" on body weight.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shahid Motahhari Clinic, Shiraz University of Medical Sciences

Shiraz, Fars, Iran

About this study

Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Body mass index (BMI) >= 25 kg/m2

Exclusion criteria

  • Diabetes mellitus
  • Hypo. or hyperthyroidism
  • Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure
  • Use of drugs: Weight lowering agents, glucocorticoids, Oral contraceptive pills.
  • Pregnancy
  • History of allergic reaction to Somagh

Treatment and study plan

Rhus Coriaria L.(Rhus)

Drug

500 mg twice daily after meals for 6 weeks

Other names: Somagh

Placebo

Drug

500 mg twice daily after meals for 6 weeks

Primary outcomes

  1. Body Mass Index

    Time frame: 6 weeks

Secondary outcomes

  1. Waist Circumference (cm)

    Time frame: 6 weeks

  2. Hip Circumference (cm)

    Time frame: 6 weeks

  3. Leptin (ng/ml)

    Time frame: 6 weeks

  4. Insulin (mU/l)

    Time frame: 6 weeks

  5. Fasting Blood Glucose (mg/dl)

    Time frame: 6 weeks

  6. Number of patients with adverse event

    Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

Shiraz University of Medical Sciences

Other

Registry information

Official study title

The Effects of Rhus Coriaria L. (Rhus or Somagh) on Body Weight

Acronym: SomaghWeight

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Apr 28, 2016
Registry last updated
Aug 23, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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