The Effects of Puberty and Weight on Sugar Metabolism in Children

Our goal is to investigate how hormones that control blood sugar, hunger, and stomach emptying change with puberty and being overweight. These substances change with a meal.

* For this, we need to compare lean and overweight children. * We need to study them before and during puberty. * All children in the study will be tested before and after a liquid meal.

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Key information

Conditions

Overweight Adolescent Body Weight Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Leanness Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Pathological Conditions, Signs and Symptoms Signs and Symptoms Thinness

Age range

8 year–17 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Baylor College of Medicine

Houston, Texas, 77030, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All groups:

Healthy lean and otherwise healthy overweight children and adolescents between the ages of 8 and 17.

Exclusion criteria

Same for all groups

The subjects will be excluded if they have:

a history of chronic disease
allergy to acetaminophen
evidence or history of chemical abuse
abnormal lab values
pregnancy

Treatment and study plan

Primary outcomes

Overweight and Lean Children Sugar Metabolism Before and During Puberty

Time frame: 4 hours

Too much weight gain can cause changes in the substances that control blood sugar and hunger in the body. Scientists need to compare these substances in lean and overweight children before and during puberty. These substances can be measured before and after a meal in the blood and in the urine. The way your stomach moves food can change your sugar levels. We want to understand how diabetes develops by studying these things. This can help find better ways to prevent and treat diabetes.

Sponsors and collaborators

Lead sponsor

Baylor College of Medicine

Other

Registry information

Official study title

The Role of Puberty and Insulin Resistance in the Development of Hyperglucagonemia

Important dates

Study start: 2012
Primary completion: 2015
Study completion: 2015
First posted: Oct 31, 2012
Registry last updated: Apr 24, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed