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Completed

NCT Number: NCT03302130

The Effects of Mood on Cerebral Perfusion

Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

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Key information

Conditions

Cerebral Perfusion

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy university students
  • between 18 and 30 years old

Exclusion criteria

  • No informed consent
  • Not using hormonal contraception
  • MRI-contraindications
  • Claustrophobia
  • Pregnancy
  • Chronic diseases and chronic medication use

Treatment and study plan

Mood induction (using own memories)

Behavioral

Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI

Arterial spin labeling MRI

Device

Single PLD PCASL

Physiological monitoring

Device

During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance

Primary outcomes

  1. Regional Cerebral perfusion (ml/100g/min) during positive mood induction

    Time frame: 2 minutes (ASL scan during mood state induction)

    Effect of positive mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

  2. Regional Cerebral perfusion (ml/100g/min) during negative mood induction

    Time frame: 2 minutes (ASL scan during mood state induction)

    Effect of negative mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

  3. Regional Cerebral perfusion (ml/100g/min) during neutral mood induction

    Time frame: 2 minutes (ASL scan during mood state induction)

    Effect of neutral mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

  4. Regional Cerebral perfusion (ml/100g/min) after positive mood induction

    Time frame: 2 minutes (ASL scan after mood state induction)

    Effect of positive mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

  5. Regional Cerebral perfusion (ml/100g/min) after negative mood induction

    Time frame: 2 minutes (ASL scan after mood state induction)

    Effect of negative mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

  6. Regional Cerebral perfusion (ml/100g/min) after neutral mood induction

    Time frame: 2 minutes (ASL scan after mood state induction)

    Effect of neutral mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

Sponsors and collaborators

Lead sponsor

University Ghent

Other

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Oct 4, 2017
Registry last updated
Nov 14, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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