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OpenTrials
Completed

NCT Number: NCT07614009

THE EFFECTS OF HPV VACCİNATİON AND MESSAGE FRAMİNG

Background: University students are at high risk for HPV infection, while HPV vaccination rates remain low. Message framing strategies may influence vaccination-related perceptions and intentions.

Objective: This study aims to compare the effects of gain- and loss-framed HPV vaccination messages on HPV risk perception, HPV knowledge, and vaccination intention among university students.

Methods: This randomized controlled experimental study includes university students from the health sciences faculty of a foundation university. Participants are assigned to gain-framed, loss-framed, and control groups. Data are collected using the Human Papillomavirus Knowledge Scale and the HPV Risk Perception Questionnaire. Statistical analyses include one-way ANOVA, two-way ANOVA, and Chi-square tests. The study is designed in accordance with CONSORT 2010 and EQUATOR Network reporting guidelines.

Keywords: message framing; gain-loss framing; human papillomavirus; vaccination

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Key information

Conditions

Human Papillomavirus (HPV) Vaccination Communicable Diseases DNA Virus Infections Disease Attributes Genital Diseases Infections Message Framing Papillomavirus Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Tumor Virus Infections Urogenital Diseases Vaccination Intention Virus Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ankara Medipol Üniversitesi

Ankara, 06000, Turkey (Türkiye)

About this study

This randomized controlled experimental study examines the effects of gain- and loss-framed HPV vaccination messages on university students' HPV knowledge, risk perception, and vaccination intention. A total of 927 university students were assigned to gain-framed, loss-framed, and control groups. The study evaluates the relationship between message framing and vaccination-related outcomes among university students.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 years or older
  • Voluntarily agrees to participate in the study
  • Has not received formal education about HPV through a course or class

Exclusion criteria

  • Has received the HPV vaccine
  • Has participated in formal education about HPV through a course or class
  • Has a current or previous positive HPV test result or HPV diagnosis

Treatment and study plan

Gain-Framed HPV Vaccination Message

Behavioral

Participants received gain-framed messages emphasizing the benefits of HPV vaccination.

Loss-Framed HPV Vaccination Message

Behavioral

Participants received loss-framed messages emphasizing the consequences of not receiving HPV vaccination.

Primary outcomes

  1. HPV vaccination intention

    Time frame: Immediately after message exposure

    Participant intention to receive the HPV vaccine measured immediately after message exposure using a self-reported vaccination intention scale.

Sponsors and collaborators

Lead sponsor

Ankara Medipol University

Other

Registry information

Official study title

THE EFFECT OF GAIN AND LOSS FRAMING MESSAGES ON RISK PERCEPTION AND KNOWLEDGE LEVELS REGARDING HPV VACCINATION AMONG UNIVERSITY STUDENTS: A RANDOMIZED CONTROLLED TRIAL

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 29, 2026
Registry last updated
May 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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