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Completed

NCT Number: NCT02825823

The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults

The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone salt, is proposed to have ergogenic potential for high-intensity exercise performance but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone salts can alter fuel use during exercise and improve exercise performance.

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Key information

Conditions

Exercise Acid-Base Imbalance Acidosis Behavior Dietary Supplements Ketones Ketosis Metabolic Diseases Motor Activity Nutritional and Metabolic Diseases

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of British Columbia, Okanagan.

Kelowna, British Columbia, V1V 1V7, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males aged 18-40
  • Ability to understand and communicate in English to answer questionnaires and interact with the research assistant
  • Physically active (defined by engaging in moderate-to-vigorous exercise at least 3 times per week, determined via validated questionnaire)

Exclusion criteria

  • Diagnosed with diabetes or any other medical conditions that could affect metabolism.
  • Diagnosed with heart disease or taking anti-hypertensive medications.
  • Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)
  • Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet
  • Current consumption of ketone supplements
  • Any other contraindication to vigorous exercise (identified via physical activity readiness questionnaire [PAR-Q])

Treatment and study plan

Ketone Salt

Dietary Supplement

Placebo

Dietary Supplement

Primary outcomes

  1. Respiratory Exchange Ratio (RER) during cycling exercise

    Time frame: 0-18 minutes

    The RER during 18 minutes of steady-state exercise

Secondary outcomes

  1. 10 km Cycling Time Trial Performance

    Time frame: Following 18 minutes of steady-state exercise

    10 km time trial performed on a stationary bicycle following 18 minutes of steady-state exercise

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jul 7, 2016
Registry last updated
Oct 13, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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