The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin

Inclusion criteria

• Eligible patients will be age between 18 and 65 who required hospitalization and parenteral antimicrobial therapy
• Clinical documentation of cellulitis / erysipela
• Documentation of a minimal surface area 75 cm2 based on the length and / or width of the redness, swelling and / or induration
• Documented fever, defined as oral or tympanic temperature greater than or equal to 38 ° C

Exclusion criteria

• Infections and other minor addition of erysipelas / cellulitis
• Any recent use of antibacterial drug therapy (systemic or topical antibacterial drugs within 14 days of enrollment)
• Patients with clinical conditions that alter the interpretation of the primary outcome as patients with neutropenia or compromised immune function, as HIV infection, autoimmune disorders, use of corticosteroids.
• Patients with known or suspected osteomyelitis.
• Patients with suspected or confirmed septic arthritis.
• Patients with complicated skin infections, such as diabetic foot infections. 7. Chronic use of antipyretic drugs (eg, daily use of naproxen).

• Less than 18 years of age. 9. pregnancy 10. Patients with mixed infections of Gram-negative or be deleted since the therapy of gram-negative can influence the levels of cytokines.

• Patients with renal clearance <30 mL / min. 12. Patients who are not susceptible to daptomycin or vancomycin. 13. Allergy to study medication.