Completed

NCT Number: NCT00002276

The Effects of AZT and Ibuprofen on HIV-Infected Patients With Hemophilia

To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.

Completed

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Key information

Conditions

HIV Infections Blood Coagulation Disorders Blood Coagulation Disorders, Inherited Blood-Borne Infections Coagulation Protein Disorders Communicable Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Genital Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hemophilia A Hemorrhagic Disorders Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Urogenital Diseases Virus Diseases

Age range

12 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hemophilia Ctr of Western PA / Univ of Pittsburgh

Pittsburgh, Pennsylvania, 15219, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients must have:

Hemophilia.
HIV-seropositivity confirmed by Western Blot.

Prior Medication:

Required:

AZT for study patients.

Allowed:

Ibuprofen.

Exclusion criteria

Co-existing Condition:

Patients with the following symptoms and conditions are excluded:

Hospitalization for opportunistic infection, bacterial infection or malignancy.

Concurrent Medication:

Excluded:

AZT (for control group).
Antibiotics or other medication for opportunistic infection, bacterial infection, or malignancy.

Patients with the following prior conditions are excluded:

Hospitalization for opportunistic infection, bacterial infection, or malignancy.

Required:

Ibuprofen.
AZT 1-2 gm daily (for study patient) or not taking AZT (for control).

Treatment and study plan

Ibuprofen

Drug

Zidovudine

Drug

Sponsors and collaborators

Lead sponsor

University of Pittsburgh

Other

Registry information

Official study title

Study of Bleeding Tendency, Platelet Function, and Pharmacokinetics of Azidothymidine (AZT) and Motrin (Ibuprofen) in HIV-Infected Hemophiliacs

Important dates

First posted: Aug 31, 2001
Registry last updated: Jun 24, 2005

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed