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OpenTrials
Completed

NCT Number: NCT05600023

The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste

In our study, we used nitrofurantoin as a root canal medication in patients suffering from symptomatic irreversible pulpitis in alleviating pain compared with double antibiotic paste.

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Key information

Conditions

Pain Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Symptomatic Irreversible Pulpitis

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Hira Danish

Karachi, Sindh, 75500, Pakistan

About this study

This study aims to compare the efficacy in alleviating pain between intracanal medicaments Nitrofurantoin versus double antibiotic paste.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No medical history
  • no history of allergy to medications used in root canal treatment
  • patients suffering from Symptomatic Irreversible Pulpitis

Exclusion criteria

  • Patients who were not suitable for conventional root canal treatment
  • multirooted teeth

Treatment and study plan

Nitrofurantoin

Drug

Nitrofurantoin has been found to successfully eradicate gram-negative bacteria such as Enterococcus faecalis that one of the most important bacteria in endodontic lesions

Double Antibiotic

Drug

DAP is a combination of two antibiotics which are ciprofloxacin and metronidazole

Primary outcomes

  1. To alleviate dental pain

    Time frame: 12 hours upto 72 hours following placement of intracanal medicament

    Dental pain will be measured by using Visual Analogue Scale(VAS) which is an 10-point scale from 0-10 where 0 represents no pain and 10 represents the worst pain measured

Sponsors and collaborators

Lead sponsor

Altamash Institute of Dental Medicine

Other

Registry information

Official study title

The Effectiveness of Single Antibiotic Paste Nitrofurantoin V/S Double Antibiotic Paste in Alleviation of Post-Operative Pain in Adult Patients Symptomatic Irreversible Pulpitis

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Oct 31, 2022
Registry last updated
Oct 31, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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