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Completed

NCT Number: NCT07449104

The Effectiveness of Dialectical Behavioral Group Psychotherapy Compared to Supportive Individual Psychotherapy In Patients With Borderline Personality Disorder: A Study on Therapeutic Alliance, Depression, Cognitive Function, Impulsivity, Suicide Risk, BDNF Levels, NFkB Levels, SOD Levels

In the context of therapy for Borderline Personality Disorder, our department had conduct a study titled "The Effectiveness of Dialectical Behavioral Group Psychotherapy Compared to Supportive Individual Psychotherapy in Patients with Borderline Personality Disorder: A Study of Therapeutic Alliance, Depression, Cognitive Function, Impulsivity, Suicide Risk, BDNF Levels, NFkB Levels, SOD Levels."

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Key information

Conditions

Borderline Personality Disorder (BPD) Behavior Behavioral Symptoms Borderline Personality Disorder Depression Impulsive Behavior Mental Disorders Personality Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical Faculty Diponegoro University

Semarang, Central Java, 50275, Indonesia

About this study

Psychotherapy for Borderline Personality Disorder provided weekly for 13 weeks. Patients have given a logbooks. Researchers monitored patients weekly by telephone and monitor them during outpatient visits in the second, fourth, sixth, eighth, and twelfth weeks. Blood samples were taken before and 13 weeks after treatment. During the study, patients were advised not to consume any medications or herbal remedies outside of those prescribed by the doctor and recorded in the study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18-60 years old
  • Diagnosed with Borderline Personality Disorder based on the Structured Clinical Interview for DSM-V Axis II Disorders (SCID-II)
  • Junior high school education or higher
  • Patients willing to participate in the study.

Exclusion criteria

  • Taking immunosuppressive drugs since one week before the study.
  • Based on interviews or medical records, there is no history of post-stroke, epilepsy, or diabetes mellitus.

Treatment and study plan

DBT group psychotherapy

Behavioral

13 weeks, one session per week. Each week, one 2-hour dialectical therapy group session for 5 patients in a group.

supportive psychotherapy

Behavioral

13 weeks, one session per week. Each week, one 30-minute session of individual supportive psychotherapy

Primary outcomes

  1. Therapeutic Alliances with California Psychotherapy Alliance Scales (CALPAS)

    Time frame: 13 weeks

    California Psychotherapy Alliance Scales (CALPAS) score. A higher CALPAS (California Psychotherapy Alliance Scale) score indicates a stronger, more positive therapeutic alliance between a patient and their therapist. The California Psychotherapy Alliance Scale (CALPAS) uses a 7-point Likert scale for its 24 items, ranging from 1 ("not at all") to 7 ("very much so"). Minimum score 24 and maximum score 168.

  2. Depression with GRID Hamilton Depression Rating Scale (GRID HAM-D)

    Time frame: 13 weeks

    GRID Hamilton Depression Rating Scale (GRID HAM-D) score, interval, higher total scores indicating greater severity of depression.

    Minimum Score: 0 (No depression) Maximum Score: 52 (Severe depression)

  3. cognitive function with Montreal Cognitive Assesment versi Indonesia (MoCA-Ina)

    Time frame: 13 weeks

    Montreal Cognitive Assesment Indonesian version (MoCA-Ina) score, interval. A 30-point screening tool validated to detect mild cognitive impairment (MCI) and dementia in Indonesia, with a score of 26 or higher considered normal.

  4. impulsivity with Barrat Impulsiveness Scale (BIS11)

    Time frame: 13 weeks

    Barrat Impulsiveness Scale (BIS11) score, interval, Higher scores indicate greater impulsivity, with 30-51 indicating low, 52-71 average, and 72+ high impulsivity.

  5. Suicide Risk with Columbia Suicide Severity Rating Scale (CSSRS)

    Time frame: 13 weeks

    Columbia Suicide Severity Rating Scale (CSSRS) score, interval, Any "Yes" answer to behavior or ideation requires further clinical assessment.

Secondary outcomes

  1. NFkB Levels in ng/ml

    Time frame: 13 weeks

    ratio scale, nanogram/mililiter

  2. BDNF level in pg/ml

    Time frame: 13 weeks

    BDNF level in picogram/mililiter, ratio scale

  3. SOD levels in ng/ml

    Time frame: 13 weeks

    ratio scale, nanogram/mililiter

Sponsors and collaborators

Lead sponsor

Natalia Dewi Wardani, MD

Other

Collaborators

  • Faculty of Medicine University of Diponegoro, Indonesia

Registry information

Acronym: DBT BPD

Important dates

Study start
2021
Primary completion
2022
Study completion
2023
First posted
Mar 4, 2026
Registry last updated
Mar 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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