Neurobehavioral Mechanisms of Moral Reasoning: an EEG Study in Patients With Borderline Personality Disorder

We will investigate social cognition in patients with Borderline personality disorder (BPD) combined with electroencephalographic (EEG) measures.

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Key information

Conditions

Borderline Personality Disorder (BPD) Borderline Personality Disorder Mental Disorders Personality Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Dep. of Psychiatry, CBF

Berlin, 12203, Germany

About this study

We will investigate whether patients with Borderline personality disorder (BPD) show a negativity bias in evaluating social situations.

We will also asses emotional arousal, theory of mind (ToM) abilities, and inhibitory control in patients with BPD.

In addition to behavioral outcome variables, electroencephalographic (EEG) measures will be recorded. Healthy controls server as a control group.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BPD diagnosis BMI between 17.5 and 30 acute major depressive episode, psychotic symptoms, substance addiction or acute suicidal behavior

Exclusion criteria

neurological, metabolic, endocrine, autoimmune and CNS diseases, any other severe somatic diseases, and pregnancy or breastfeeding during the last 12 months

Treatment and study plan

Primary outcomes

Number of accidental harm scenarios misclassified as intentional

Time frame: 20 Minutes

Accuracy

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Jul 29, 2025
Registry last updated: Jul 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed