The Effect of Sponge Versus No-Sponge Placement of Mitomycin-C on the Outcomes of Trabeculectomy With Ex-PRESS Glaucoma Filtration Device

Inclusion criteria

• Men or women aged 18 years and older at screening.
• Diagnosis of chronic angle-closure glaucoma or open-angle glaucoma, phakic or pseudophakic, with visual field or optic disc changes characteristic of glaucoma.
• Suitable candidate for trabeculectomy with Ex-PRESS glaucoma filtration device with MMC in the superonasal quadrant in the study eye which the physician deems as medically necessary.
• Capable and willing to provide consent

Exclusion criteria

• Unable or unwilling to provide consent
• Any previous ocular surgeries in the study eye preventing placement of the trabeculectomy with Ex-PRESS glaucoma filtration device with mitomycin-C in the superonasal quadrant
• Any previous glaucoma drainage devices in the study eye
• Any abnormality other than glaucoma in the study eye that could affect applanation tonometry.
• Presence or history of any abnormality or disorder that could interfere with the study procedure or prevent the successful completion of the study.
• Presence or history of uveitis within 10 years or any other ocular infection or inflammation within 14 days before day 1.
• Any significant unstable cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, neurologic, or psychiatric disease.
• Known Pregnancy or Breastfeeding

Physical and Laboratory Findings

• Conjunctival scarring precluding a superonasal implantation location.
• Vitreous in the anterior chamber.
• Abnormality preventing reliable applanation tonometry in the study eye.