The Effect of Sodium Alginate on Appetite Sensation

The project consists of two different studies:

Study I: A randomised controled meal test study aimed at studying the acute effect of the alginate-containing beverage on appetite sensation and spontaneous calorie intake (and safety i.e. nausea, well-being etc) in normal to overweight healthy subjects. Here, a placebo beverage or the alginate-containing beverage will be administered as a pre-load before a standardised breakfast meal. Subjective appetite sensation will be measured with Visual Analogue Scale (VAS) every 30 minutes four up to 5 hours. An additional beverage will be administered prior to an ad libitum lunch meal, where spontaneous water and energy intake will be registered.

Study II: Secondly the aim is to study the effects of a daily intake of a placebo or alginate-containing beverage on body weight and composition in a randomised parallel intervention study of 12 weeks duration. A total of app. 50 obese healthy adults will receive a hypocaloric diet and be randomised to consume either placebo or alginate-containing beverage before each of the three main meals every day. The development in body weight and composition and blood pressure will be monitored and blood samples will be analysed for markers related to the risk of CVD and type 2 diabetes.

Inclusion criteria

• Healthy men and women
• Normal to slight overweight (BMI: 22-28 kg/m2)
• 20-45 years of age

Exclusion criteria

• Smoking
• Daily medicine use (oral contraceptives excluded)
• Use of dietary supplements
• Blood donation 3 months prior to the study
• Hb<7.5 mmol/l
• Chronic illnesses such as hyperlipidemia, diabetes and inflammatory diseases
• Pregnancy or breastfeeding
• Elite athletes (>10 hours hard exercise/week)
• Vegetarians