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NCT Number: NCT07050264

The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments

Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.

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Key information

Conditions

Burn Injury Body Temperature Regulation Burns Cardiovascular Physiology Wounds and Injuries

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas

Dallas, Texas, 75231, United States

Location status: Recruiting

Location contact

Craig G Crandall, PhD

CONTACT

[email protected]

Elizabeth A Gideon, PhD

SUB_INVESTIGATOR

Erin M Harper, B.S.

CONTACT

[email protected]

214-345-4737

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 and 65 years of age
  • free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.

Exclusion criteria

  • Known heart disease
  • other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc. as well as serious abnormalities detected on routine screening.
  • Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test.
  • Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response.
  • Current smokers, as well as individuals who regularly smoked within the past 3 years.
  • body mass index is ≥ 31 kg/m2.

Treatment and study plan

Simulated burn injury via application of absorbent and impermeable material over 60% of the body

Other

Simulated burn injury via application of absorbent and impermeable material over 60% of the body

Primary outcomes

  1. Core Temperature

    Time frame: From baseline to end of 60 minutes of recovery

Secondary outcomes

  1. Heart Rate

    Time frame: From baseline to the end of 60 minutes of recovery

Study contacts

Contact information is provided by the study sponsor or research team.

Elizabeth A Gideon, PhD

CONTACT

[email protected]

Erin M Harper, B.S.

CONTACT

[email protected]

12143454737

Sponsors and collaborators

Lead sponsor

University of Texas Southwestern Medical Center

Other

Collaborators

  • National Institute of General Medical Sciences (NIGMS)

Registry information

Acronym: HSR

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jul 3, 2025
Registry last updated
May 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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