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Recruiting

NCT Number: NCT07643545

Mitochondrial Energy Metabolism in Burns

The goal of this observational study is to assess the impact of burn injury on cellular energetics in patients that have been admitted to the burn center at Arkansas Children's Hospital for burn care and require one or more procedures to clean, debride, and repair burn wounds will be eligible to participate in this study.

During the study, we will collect the following information:

* General background information such as date of birth, height, weight, and other basic information. * Medical information, such as: basic medical information, details of burn injury, vital signs on the day of surgery, medicines you take during your stay, and some clinical tests. * Blood, urine, and tissue during surgeries you have during your stay.

Recruiting

Interested in participating?

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Key information

Conditions

Burn Injury Burns Wounds and Injuries

Age range

2 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States

Location status: Recruiting

Location contact

Craig Porter, PhD

PRINCIPAL_INVESTIGATOR

Daniel Lozano, MD

SUB_INVESTIGATOR

Esther Teo, MD

SUB_INVESTIGATOR

Mandy Yelvington, MS, OTR/L

SUB_INVESTIGATOR

Richard Yeager, MD

SUB_INVESTIGATOR

Robert Maxson, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or Female
  • Ages 2 years to 80 years
  • Requiring hospital admission for burn care
  • All races
  • All ethnicities

Exclusion criteria

  • Age < 2 years
  • Under 10 kg in body mass
  • Age > 80 years
  • Active pregnancy
  • Unable to provide informed consent and no legal authorized representative present
  • Patient is considered moribund at the time of admission by the treating physician.

Treatment and study plan

Primary outcomes

  1. Blood Bioenergetics

    Time frame: Through study completion, an average of 1 year

    Peripheral Blood Mononuclear Cell (PBMC) respiration

Secondary outcomes

  1. Blood metabolics signatures

    Time frame: Through study completion, an average of 1 year

    Peripheral Blood Mononuclear Cell (PBMC) respiration

Study contacts

Contact information is provided by the study sponsor or research team.

Craig Porter, PhD

CONTACT

[email protected]

5013643340

Lily Cheak, B.S.

CONTACT

[email protected]

5013643340

Sponsors and collaborators

Lead sponsor

Arkansas Children's Hospital Research Institute

Other

Collaborators

  • National Institute of General Medical Sciences (NIGMS)

Registry information

Official study title

The Role of the Mitochondrian in the Metabolic Stress Response to Burn Trauma

Acronym: Mito Burn

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jun 11, 2026
Registry last updated
Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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