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NCT Number: NCT06957158

The Effect of Serum Calcium Levels on Postoperative Pain: A Prospective Observational Study

This is a prospective observational study. To investigate the effect of serum calcium levels on postoperative pain in patients undergoing abdominal surgery, and to determine whether changes in serum calcium levels are a risk factor for postoperative pain.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400010, China

Location status: Recruiting

Location contact

Guangyou Duan, PhD

CONTACT

[email protected]

+86 183 2337 6014

Guangyou Duan, PhD

PRINCIPAL_INVESTIGATOR

About this study

This study aimed to measure the total serum calcium and ionized calcium levels both before and after surgery. Additionally, NRS scores were recorded at different time points.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18-70 years old
  • American Society of Anesthesiologists Classification I-III
  • Patients undergoing elective abdominal surgery under general anesthesia
  • Patients participate voluntarily and sign an informed consent form

Exclusion criteria

  • Patients with a history of severe disease
  • Patients with chronic preoperative pain and/or long-term analgesic use
  • Patients with hearing disorders or verbal communication difficulties
  • Patients with psychiatric disorders or cognitive dysfunction
  • Patients requiring mechanical ventilation or ICU admission after surgery
  • Patients with a history of substance or alcohol abuse Patients who could not cooperate with the study for any reason

Treatment and study plan

Peripheral venous blood

Diagnostic Test

Peripheral venous blood was collected before and after the surgery to measure the total serum calcium levels.

Arterial blood

Diagnostic Test

Arterial blood was collected before anesthesia induction and after removal of the artificial airway to measure ionized calcium levels.

Primary outcomes

  1. The incidence of pain NRS score ≥6 within 48 hours after surgery

    Time frame: From the end of the surgery to 48 hours after surgery

    NRS score: pain was assessed using a 10-point NRS (range: 0-10, 0 and 10 indicate no pain and the most extreme pain imaginable, respectively）

Secondary outcomes

  1. The maximum incisional pain score at 0-12h postoperatively

    Time frame: From the end of the surgery to 12 hours after surgery

    NRS score: pain was assessed using a 10-point NRS (range: 0-10, 0 and 10 indicate no pain and the most extreme pain imaginable, respectively）

  2. The maximum incisional pain score at 12-24h postoperatively

    Time frame: From 12hours to 24 hours after surgery

    NRS score: pain was assessed using a 10-point NRS (range: 0-10, 0 and 10 indicate no pain and the most extreme pain imaginable, respectively）

  3. The maximum incisional pain score at 24-48h postoperatively

    Time frame: From 24 hours to 48 hours after surgery

    NRS score: pain was assessed using a 10-point NRS (range: 0-10, 0 and 10 indicate no pain and the most extreme pain imaginable, respectively）

  4. The maximum visceral pain score at 0-12h postoperatively

    Time frame: From the end of the surgery to 12 hours after surgery

    NRS score: pain was assessed using a 10-point NRS (range: 0-10, 0 and 10 indicate no pain and the most extreme pain imaginable, respectively）

  5. The maximum visceral pain score at 12-24h postoperatively

    Time frame: From 12 hours to 24 hours after surgery

    NRS score: pain was assessed using a 10-point NRS (range: 0-10, 0 and 10 indicate no pain and the most extreme pain imaginable, respectively）

  6. The maximum visceral pain score at 24-48h postoperatively

    Time frame: From 24 hours to 48 hours after surgery

    NRS score: pain was assessed using a 10-point NRS (range: 0-10, 0 and 10 indicate no pain and the most extreme pain imaginable, respectively）

  7. Whether additional analgesia was administered within 48 hours after surgery

    Time frame: From the end of the surgery to 48 hours after surgery

    The proportion of patients who received additional analgesia out of the total patient group

  8. Patient-controlled intravenous analgesia opioid consumption

    Time frame: From the end of the surgery to 24 hours and 48 hours after surgery

    PCIA opioid consumption was assessed by checking the PCIA electronic system

Study contacts

Contact information is provided by the study sponsor or research team.

Guangyou Duan, PhD

CONTACT

[email protected]

+86 183 2337 6014

Sponsors and collaborators

Lead sponsor

The Second Affiliated Hospital of Chongqing Medical University

Other

Registry information

Official study title

The Effect of Serum Calcium Levels on Postoperative Pain in Patients Undergoing Abdominal Surgery: A Prospective Observational Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 4, 2025
Registry last updated
Jun 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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