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NCT Number: NCT07458360

FRONT Block for Quality of Recovery After Total Hip Arthroplasty

This prospective randomized controlled trial evaluates the effect of ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block on postoperative quality of recovery in patients undergoing elective total hip arthroplasty.

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Key information

Conditions

Osteoarthritis of the Hip Arthritis Joint Diseases Musculoskeletal Diseases Neurologic Manifestations Osteoarthritis Osteoarthritis, Hip Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Pain Quality of Recovery Rheumatic Diseases Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Total hip arthroplasty (THA) is associated with significant postoperative pain that may impair early recovery. The Femoral Rami and Obturator Nerve Trunk (FRONT) block is a regional anesthesia technique targeting sensory innervation of the anterior hip capsule and may improve postoperative recovery while preserving motor function. This prospective randomized controlled trial aims to evaluate whether the addition of ultrasound-guided unilateral FRONT block to standard multimodal analgesia improves postoperative quality of recovery in patients undergoing THA.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Scheduled for total hip arthroplasty under spinal anesthesia
  • American Society of Anesthesiologists (ASA) physical status I-III
  • Ability to understand and complete the QoR-15 questionnaire
  • Provided written informed consent

Exclusion criteria

  • Refusal to participate
  • Contraindication to spinal anesthesia or regional block
  • Allergy to study medications
  • Chronic opioid use (daily use for more than 3 months)
  • Neurological or neuromuscular disorders affecting the lower extremities
  • Infection at the injection site
  • Coagulation disorders
  • Cognitive impairment prevents questionnaire completion

Treatment and study plan

FRONT Block (Femoral Rami and Obturator Nerve Trunk Block)

Procedure

Ultrasound-guided unilateral FRONT block targeting the femoral rami and obturator nerve trunk will be performed

Standard Multimodal Analgesia

Procedure

Standardized postoperative multimodal analgesia including intravenous paracetamol, nonsteroidal anti-inflammatory drugs, and rescue opioid analgesia as required.

Primary outcomes

  1. Postoperative Quality of Recovery (QoR-15 Score)

    Time frame: 24 hours after surgery

    Postoperative quality of recovery will be assessed using the validated Quality of Recovery-15 (QoR-15) questionnaire. The total score ranges from 0 to 150, with higher scores indicating better recovery.

Secondary outcomes

  1. Quality of Recovery (QoR-15) Score at 48 Hours

    Time frame: 48 hours after surgery

    Quality of recovery will be assessed using the validated Quality of Recovery-15 (QoR-15) questionnaire (0-150, higher scores indicate better recovery).

  2. Postoperative Pain Intensity

    Time frame: 2, 6, 12, 24, and 48 hours after surgery

    Pain intensity will be assessed using an 11-point Numeric Rating Scale (NRS), where 0 indicates no pain and 10 indicates the worst imaginable pain.

  3. Total Opioid Consumption

    Time frame: 0-24 hours after surgery

    Total postoperative opioid consumption during the first 24 hours will be recorded and converted to intravenous morphine milligram equivalents (MME).

  4. Time to First Rescue Analgesia

    Time frame: Within the first 24 hours after surgery

    Time from the end of surgery to the first rescue opioid administration will be recorded

  5. Time to First Mobilization

    Time frame: Within the first 48 hours after surgery

    Time from the end of surgery to first assisted ambulation will be recorded

  6. Quadriceps Motor Strength

    Time frame: 0-48 hours after surgery

    Quadriceps muscle strength will be evaluated using the Medical Research Council (MRC) scale ranging from 0 (no contraction) to 5 (normal muscle strength).

Sponsors and collaborators

Lead sponsor

Konya Meram State Hospital

Other

Registry information

Official study title

Effect of Femoral Rami and Obturator Nerve Trunk (FRONT) Block on Postoperative Quality of Recovery After Total Hip Arthroplasty: A Prospective Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 9, 2026
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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