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Completed

NCT Number: NCT05042167

The Effect of Resistance Exercise on Inflammation in Young and Older Adults

Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.

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Key information

Conditions

Aging Inflammatory Response

Age range

20 year–80 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan Normal University

Taipei, 162, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 20-80
  • Healthy male
  • Without experience of resistance training

Exclusion criteria

  • No acute or chronic musculoskeletal symptoms
  • Smoking
  • Alcohol or drug abuse
  • Fail to conduct resistance exercise

Treatment and study plan

Resistance Exercise

Other

4 total resistance exercises that target all major muscle groups.

Primary outcomes

  1. Changes in biomarkers of inflammation

    Time frame: 24-hour during each study intervention

    Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.

Secondary outcomes

  1. Changes in glucose

    Time frame: 24-hour during each study intervention

    glucose in mg/dL

  2. Changes in metabolic parameters

    Time frame: 24-hour during each study intervention

    Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL.

  3. Changes in biomarkers of muscle damage

    Time frame: 24-hour during each study intervention

    Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.

  4. Changes in molecular markers in peripheral blood mononuclear cells (PBMC)

    Time frame: 24-hour during each study intervention

    Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units.

  5. Changes in complete blood count (CBC)

    Time frame: 24-hour during each study intervention

    The white blood cell count and the count of each white blood cell type will be measured.

  6. Borgs Ratings of Perceived Exertion (RPE)

    Time frame: 1-hour during each exercise intervention

    Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).

Sponsors and collaborators

Lead sponsor

National Taiwan Normal University

Other

Registry information

Official study title

The Acute Effect of High-load Resistance Exercise on Inflammation in Young and Older Adults

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Sep 13, 2021
Registry last updated
Jan 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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