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NCT Number: NCT05209958

The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy

The aim of this study is to investigate the relationship of preoperative Neutrophil/Lymphocyte Ratio (NLR) with postoperative pain and the effect of preoperative NLR level on timing of epidural analgesia in thoracotomy.

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Key information

Conditions

C23.550.767.700 C23.550.470 Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

KaradenızTU

Trabzon, Turkey (Türkiye)

About this study

The study was conducted prospectively in 60 patients aged 18-75 years, ASA I-III, who underwent thoracotomy. The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28). Each group was divided into subgroups with equal numbers of Prempative analgesia group and control group. Local anesthetic was administered to the preemptive analgesia group (Group P) 20 minutes before the surgical incision through the epidural catheter, and to the control group (Group K) 20 minutes before the patient was awakened from the epidural catheter. NRS levels and additional analgesia needs were recorded at 2, 4, 8, 12 and 24 hours postoperatively.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient graded as American Society of Anesthesiologist (ASA) physical status, I, II or III
  • Patient subjected to thoracotomy operation

Exclusion criteria

Patient having morbid obesity,

  • Patient having renal failure,
  • Patient having hepatic failure,
  • Patient having neuropsychiatric disease,
  • Patient allergy to the study drugs

Treatment and study plan

Neutrophil Lynphosite ratio

Diagnostic Test

The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28).

Primary outcomes

  1. preoperative neutrophil lymphoycte ratio

    Time frame: 24 hours before the operation

    To determine the epidural application with preoperative neutrophil lymphoycte ratio

  2. Postoperative opioid requiremen Postoperative opioid requirement

    Time frame: postoperative first 24 hour

    Postoperative opioid requirement for pain relief

Secondary outcomes

  1. Numerical Pain Rating Scale

    Time frame: postoperative first 24 hour

    Numerical Pain Rating Scale in postoperative period

Sponsors and collaborators

Lead sponsor

Karadeniz Technical University

Other

Registry information

Important dates

Study start
2020
Primary completion
2021
Study completion
2022
First posted
Jan 27, 2022
Registry last updated
Jan 27, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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