The Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lobectomy

The primary objective is to evaluate the impact of oliceridine administered via patient controlled analgesia device（PCA）versus sufentanil administered via PCA on the incidence of chronic postsurgical pain (CPSP) in patients undergoing video-assisted thoracoscopic surgery.

Inclusion criteria

• ① Age 18-75 years, ASA physical status I-III, BMI 18-30 kg/m²;

• Scheduled for unilateral video-assisted thoracoscopic surgery (VATS) lung resection, including wedge resection, segmentectomy, lobectomy, or radical resection for lung cancer;

• Preoperative pain score <1 on the Numeric Rating Scale (NRS);

• Ability to understand the study objectives and procedures, with voluntary informed consent obtained;

• Expected postoperative recovery in the general ward setting.

Exclusion criteria

• ① History of chronic pain or long-term analgesic use prior to surgery;

• Previous ipsilateral thoracic surgery;

• Prior neoadjuvant radiotherapy or chemotherapy;

• Severe cardiovascular or cerebrovascular disease, or hepatic/renal dysfunction (ALT/AST >3× upper limit of normal; eGFR <60 mL/min/1.73m²);

• Concurrent malignancy or active infection;

• Pre-existing psychiatric disorders or communication barriers precluding study participation;

• Known hypersensitivity to study medications (opioids, adjuvant analgesics, anesthetics, or antiemetics);

• Any condition deemed unsuitable for study participation by the investigator