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NCT Number: NCT07717151

Prevention of Chronic Postsurgical Pain in Chronic Opioid Users:

Chronic opioid users undergoing surgery are at increased risk of CPSP, contributing to long-term disability, decreased quality of life, and prolonged opioid exposure. Existing preventive strategies remain limited, and early postoperative monitoring may represent a key opportunity for intervention. Evidence suggests that transitional pain services can improve outcomes by optimizing pain control and reducing long-term opioid consumption, but implementation is heterogeneous and often resource-intensive. Telemedicine offers a scalable alternative, enabling early specialized evaluation and timely therapeutic adjustments while maintaining accessibility. This randomized controlled trial will compare standard postoperative follow-up with standard follow-up plus a specialized teleconsultation performed between postoperative day 15 and 28. The intervention aims to detect insufficiently controlled pain, signs of neuropathic pain, or maladaptive opioid use, and to propose individualized therapeutic adjustments when required.

Participants will be followed for 6 months. Primary assessment will occur at 3 months to determine CPSP incidence. Secondary assessments will include pain trajectory (intensity, neuropathic features, functional interference), opioid consumption and misuse, quality of life, and a descriptive medico- economic evaluation

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Key information

Conditions

Chronic Postsurgical Pain Chronic Opioid Users Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Perioperative Medicine Postoperative Complications Postoperative Pain Signs and Symptoms Transitional Pain Service

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Amiens-Picardie

Amiens, 80054, France

Location status: Recruiting

Location contact

Ottilie Fumery, MD

SUB_INVESTIGATOR

Paul TARPIN, MD

CONTACT

[email protected]

0322087980

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years
  • Elective non-urgent surgery with expected moderate or higher postoperative pain
  • Chronic preoperative opioid use
  • Written informed consent
  • affiliated with a national social security scheme

Exclusion criteria

  • Ambulatory surgery
  • Endoscopic or palliative surgery
  • Patients receiving opioid substitution therapy
  • Non-medical opioid use
  • Intrathecal/epidural analgesia or implanted neurostimulator
  • Legally protected adults
  • Severe psychiatric or neurodegenerative disorders

Treatment and study plan

standard institutional perioperative management

Other

standard institutional perioperative management

specialized teleconsultation

Other

Patients in the intervention arm participate in a specialized teleconsultation between postoperative day 15-28 to detect poorly controlled pain, neuropathic features, or opioid-related concerns, and to adjust treatment if needed.

Primary outcomes

  1. Incidence of chronic postsurgical pain (CPSP)

    Time frame: at 3 months

    Incidence of chronic postsurgical pain (CPSP) at 3 months, defined as:

    • new or aggravated postsurgical pain located at the surgical site or innervated territory,
    • persistent for ≥3 months,
    • intensity ≥3/10 (new pain) or increase ≥2/10 from baseline (aggravation),
    • with significant functional impact (≥3/10 on at least one Brief Pain Inventory interference item),
    • assessed at day 90 ±14.

Secondary outcomes

  1. Pain trajectory

    Time frame: at 3 months

    Pain trajectory is measured by using intensity (BPI), + neuropathic features (DN4) +Quality of life (EQ-5D-5L)

  2. Pain trajectory

    Time frame: at 6 months

    Pain trajectory is measured with intensity (BPI), neuropathic features (DN4), Quality of life (EQ-5D- 5L)

  3. Opioid use

    Time frame: at 3 months

    Opioid use is defined as oral morphine equivalent consumption, proportion with reduction/discontinuation, POMI-5F, SOWS, DSM-5 OUD criteria

  4. Opioid use

    Time frame: at 6 months

    Opioid use is defined as oral morphine equivalent consumption, proportion with reduction/discontinuation, POMI-5F, SOWS, DSM-5 OUD criteria

  5. Descriptive medico-economic analysis

    Time frame: at 6 months

    Descriptive medico-economic analysis is determined with assessment of direct and indirect costs, descriptive comparison of effectiveness (incidence of CPSP at 6 months),descriptive reporting of utility values derived from EQ-5D-5L at 6 months

Study contacts

Contact information is provided by the study sponsor or research team.

Paul Tarpin, MD

CONTACT

[email protected]

33+3.22.08.79.80

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Official study title

Ransitional Teleconsultation to Prevent Chronic Postsurgical Pain in Chronic Opioid Users

Acronym: PRE-OPIOID

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Jul 21, 2026
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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