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NCT Number: NCT06555107

Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery

Studies evaluating postoperative pain as a risk factor for CPSP are almost exclusively carried out in the context of scheduled surgery. As a result, the preoperative pain studied as a risk factor for chronicity is essentially a state of pain that has persisted for several weeks or even several months.

In emergency surgeries, patients are subject to acute preoperative pain of varying intensity and the duration of which may vary by a few days. A few studies have highlighted the intensity of acute preoperative pain as a factor favouring moderate to severe postoperative pain. At this point, no study has addressed the long-term consequences of this intense preoperative pain the emergency context.

An evaluation in the field of emergency surgery, where the preoperative pain is often intense and limited in time, would enable us to identify more precisely the impact of acute pain on the incidence of CPSP.

The investigators are hypothesising that the occurrence of CPSP at 3 months in patients undergoing emergency orthopaedic or abdominal surgery is associated with acute preoperative pain.

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Key information

Conditions

Chronic Postsurgical Pain Acute Pain Emergency Surgery Neurologic Manifestations Opioid Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Pain Risk Factors Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Amiens-Picardie

Amiens, 80054, France

Location status: Recruiting

Location contact

Benjamin Mestan, MD

SUB_INVESTIGATOR

Ottilie Fumery, MD

SUB_INVESTIGATOR

Paul TARPIN, MD

CONTACT

[email protected]

0322087980

Stephane BAR, Pr

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years old.
  • Emergency orthopaedic and/or abdominal surgery.
  • Informed consent.
  • Affiliation to a social security scheme

Exclusion criteria

  • Intraoperative complications that are life-threatening or require the surgical procedure to be discontinued.
  • Post-operative intensive care unit admission.
  • Ambulatory surgery.
  • Endoscopic surgery.
  • Repeat surgery at the same site in less that 3months.
  • Pregnant or breast-feeding patients.
  • Patients under guardianship or deprived of liberty.
  • Patients suffering from psychiatric pathologies.
  • Patients suffering from neurodegenerative pathologies.
  • Patients for whom self-assessment of pain using a numerical scale (0-10) cannot be carried out (non-communicative patients, non-French-speaking patients, and so on).

Treatment and study plan

Questionnaire

Other

Patients included in the study will be asked to complete a questionnaire 48 to 72 hours after surgery to assess their perception of pain and preoperative anxiety

phone call

Other

Patients will then be interviewed by phone 3 months after their emergency surgery. During the interview, they will be questioned via a standardised questionnaire on the existence of CPSP

Primary outcomes

  1. Frequency of CPSP

    Time frame: at 3 months

Study contacts

Contact information is provided by the study sponsor or research team.

Paul TARPIN, Dr

CONTACT

[email protected]

0322087980

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: POCSE

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Aug 15, 2024
Registry last updated
Jan 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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