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NCT Number: NCT07688382

The Effect of Lavender Aromatherapy on Cognitive Function in Older Adults With Mild Cognitive Impairment

1. To analyze the therapeutic effects of lavender aromatherapy on memory function and overall cognitive function in older adults with Mild Cognitive Impairment (MCI); 2. To analyze whether lavender aromatherapy improves executive function, language ability, attention, visuospatial ability, anxiety, depression, quality of life, and sleep in older adults with MCI.

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Key information

Conditions

MCI

Age range

60 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

The intervention protocol was established as follows: Based on the elderly participant's usual bedtime, the time of going to bed was recorded. The participant was instructed to assume a comfortable sleeping position, use the graduated dropper provided with the essential oil bottle to measure 0.15 ml (approximately 3 drops; theoretically, 0.05 ml per drop) of diluted lavender essential oil, and drip it vertically onto the upper center of a cotton pad. The cotton pad was then pinned to the collar with a safety pin, and the participant was instructed to inhale the scent evenly for 30 minutes. Afterward, the intervention staff or caregiver will remove the cotton pad. The intervention will be conducted 5 days a week for 12 weeks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The MCI mentioned in this study meets the diagnostic criteria proposed by the *Chinese Expert Consensus on the Diagnosis and Treatment of Alzheimer's Disease-Derived Mild Cognitive Impairment (2021)*: cognitive impairment reported by the patient or an informant, or identified by an experienced clinician; objective evidence of impairment in one or more cognitive domains, with episodic memory impairment being the most common; complex instrumental activities of daily living may be mildly impaired, but the ability to perform basic activities of daily living remains independent; the diagnostic criteria for dementia are not met.
  • MoCA-Beijing version scores were adjusted for education level: ≤13 for junior high school education or below, ≤19 for high school education, and ≤24 for university education or above; MMSE score >24; ADL score <23.
  • Age between 60 and 79 years.
  • Normal olfactory function assessed using the "Sniffin' Sticks" test.
  • Ability to communicate normally and complete cognitive assessments.
  • Residing in a senior care facility with no plans to leave within the next 12 weeks.

Exclusion criteria

  • Presence of other conditions known to affect cognitive function, such as psychiatric disorders (e.g., schizophrenia, depression).
  • History of asthma or any allergic conditions.
  • Use of any prescription medications that may impact cognitive function (including psychotropic drugs and others)

Treatment and study plan

Aromatherapy

Other

Participants in the intervention group will receive aromatherapy inhalation for 30 minutes per session, five times a week, over a period of 12 week

Primary outcomes

  1. Gobal cognitive function

    Time frame: Week 12

    Use the Mini-Mental State Examination to assess overall cognitive function.

  2. Memory

    Time frame: Week 12

    Use the Auditory Verbal Learning Test to assess memory function.

Secondary outcomes

  1. Language function

    Time frame: Week 12

    Use the Boston Naming Test to assess Language function

  2. Executive function

    Time frame: Week 12

    Use the TMT-B to assess Executive function

  3. Visual space

    Time frame: Week 12

    Use the Draw-a-Clock Test to assess Visual space

  4. Attention

    Time frame: Week 12

    Use the TMT-A to assess Attention

  5. Anxiety

    Time frame: Week 12

    Use the 15-item Geriatric Depression Scale to assess Anxiety

  6. Depression

    Time frame: Week 12

    Use the 15-item Geriatric Depression Scale to assess Depression

  7. Sleep Quality

    Time frame: Week 12

    Use the Pittsburgh Sleep Quality Index to assess Depression

  8. Quality of Life assess

    Time frame: Week 12

    Use the ShortForm 8 Health Survey Questionnaire to assess Depression

Study contacts

Contact information is provided by the study sponsor or research team.

Yuxin Zhang, Graduate

CONTACT

[email protected]

18867845231

Sponsors and collaborators

Lead sponsor

China Medical University, China

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 7, 2026
Registry last updated
Jul 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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