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Completed

NCT Number: NCT00333905

The Effect of Ischemic Training on Exercise Endurance

The purpose of this study is to determine if reducing blood flow to an exercising muscle during exercise training will enhance the training effect on that muscle in people who have limited exercise because of congestive heart failure

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Key information

Conditions

Heart Failure Behavior Cardiovascular Disease Cardiovascular Diseases Congestive Heart Failure Heart Diseases Motor Activity

Age range

30 year–71 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

New Mexico VA Health Care System

Albuquerque, New Mexico, 87108, United States

About this study

The objective of this study is to determine whether reduction of blood flow during stair-stepping and cycling ergometer leg exercise will contribute to an improvement in whole body exercise capacity or submaximal exercise endurance in patients with mild congestive heart failure. Two groups of 25 patients with mild to moderate CHF, aged 30-70, will be trained for 12 weeks. The experimental group will train with pressure cuffs inflated on one thigh and lower leg during exercise. The cuff will be applied on alternate legs during training, such that each leg has the same duration of ischemic training. The control group will train for a similar duration and intensity without pressure cuffs on the legs. Pre and post training measures will include VO2peak, exercise duration at 30% VO2peak, 6 minute walk test, Minnesota Living with Heart Failure questionnaire

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Mild Congestive Heart Failure
  • Must be able to exercise

Exclusion criteria

  • Venous or arterial thrombus
  • Lower extremity arthritis
  • Blood clotting abnormalities
  • Claudication
  • Peripheral vascular disease
  • Evidence of deep vein thrombosis on ultrasound

Treatment and study plan

Ischemic exercise training

Procedure

Primary outcomes

  1. Exercise duration before and after 12 weeks of training during a submaximal exercise test and distance walked on a 6-minute walk test.

Secondary outcomes

  1. Peak cycle ergometer VO2max test before and after training

Sponsors and collaborators

Lead sponsor

US Department of Veterans Affairs

Fed

Registry information

Important dates

Study start
2006
Study completion
2008
First posted
Jun 6, 2006
Registry last updated
Feb 5, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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