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Completed

NCT Number: NCT01907841

The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage

Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.

Therefore the purpose of this study is to:

1. Quantify the use of IPC in recovery following EIMD. 2. Identify any effect of IPC during recovery on muscle function

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Key information

Conditions

Exercise-induced Muscle Damage

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

St Marys Umiversity College

London, TW1 4SX, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physically Active Males

Exclusion criteria

  • Muscular skeletal disorders

Treatment and study plan

Ischemic Preconditioning

Other

Primary outcomes

  1. Change from baseline in maximal voluntary contraction

    Time frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

    Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition.

    The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions.

Secondary outcomes

  1. Change from baseline in Creatine kinase

    Time frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

    Plasma CK was determined from an earlobe capillary blood sample. The sample (10 microlitres) was analysed immediately using an semi-automated clinical chemistry analyser.

    The change in CK will be determined 24, 48 and 72 hours following pre exercise conditions

  2. Change from baseline in Limb girth

    Time frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

    Mid-thigh and calf circumference was assessed as a measure of limb swelling using an anthropometric tape measure. Both measures were obtained with the participant in a standing position.

    The change in limb girth will be determined 24, 48 and 72 hours following pre exercise conditions

  3. Chnage from baseline in Vertical jump

    Time frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

    Vertical jump (VJ) performance was assessed using an electronic timing mat with hands placed on hips and participants dropping down to a self-selected level before jumping maximally.

    The change in VJ will be determined 24, 48 and 72 hours following pre exercise conditions

  4. Change from baseline in Muscle soreness

    Time frame: pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

    Muscle soreness - Participants were asked to perform and hold a squat (90° knee angle) whilst they rated their perceived muscle soreness on a 200 mm visual analogue scale. The scale consisted of a line from 0 mm (no pain) to 200 mm (unbearably painful).

    The change in muscle soreness will be determined 24, 48 and 72 hours following pre exercise conditions

Sponsors and collaborators

Lead sponsor

St Mary's University College

Other

Registry information

Official study title

The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage: a Randomized Control Trial

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Jul 25, 2013
Registry last updated
Mar 6, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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