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Completed

NCT Number: NCT07352319

DOES LOWER BODY PLYOMETRICS CAUSE RHABDOMYOLYSIS IN FEMALE VOLLEYBALL PLAYERS-AN EXPERIMENTAL STUDY

Eight-week interventional study to evaluate whether lower-body plyometric training alters serum creatine phosphokinase (CPK) and creatinine levels in female collegiate volleyball players. Sixty participants were randomized to experimental (plyometrics twice weekly) or control (routine volleyball) groups. Blood sampling occurred at baseline; days 2, 4, and 6; and weeks 1, 2, 4, 6, and 8.

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Key information

Conditions

Exercise-induced Muscle Damage Athletes Muscular Diseases Musculoskeletal Diseases Rhabdomyolysis

Age range

18 year–25 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Dr. Mariam Salem

Jeddah, 32143, Saudi Arabia

About this study

Intervention adapted from James & Robert (2015). Experimental group completed progressive lower-body plyometrics twice weekly (Monday/Wednesday) over eight weeks with warm-up and cool-down. Exercises included squat jump; jump to box (30 cm); tuck jump; split squat jump; lateral hurdle jump (50 cm); zigzag jump; single-leg tuck jump; and depth jump (80 cm). Control group continued routine volleyball activities and did not perform low/medium/high-intensity plyometrics. Primary biomarker (serum CPK) assessed via CK-NAC optimized IFCC method; serum creatinine by modified Jaffe's method. Two-way ANOVA with Bonferroni post hoc used. Findings: CPK increased from day 2, peaked day 4, stabilized to week 2, then declined toward baseline by week 8; creatinine remained stable.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Active collegiate female volleyball players

  • consent to participate
  • no prior plyometric training program.

Exclusion criteria

  • Neuromuscular impairments
  • recent injuries.

Treatment and study plan

plyometric program

Other

Twice-weekly sessions (Mon/Wed) for 8 weeks; exercise menu and dosing per Table 1 (intensity, rest, and jumps/set).

Other names: Lower-body plyometric training

Primary outcomes

  1. Serum CPK (U/L)

    Time frame: Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks

    change from baseline at day 2, day 4, week 1, week 2, week 4, week 6, week 8

Secondary outcomes

  1. Serum creatinine (mg/dL)

    Time frame: Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks

    change from baseline over same time points

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effects of Lower Body Plyometric Training on Serum CPK and Creatinine Levels in Collegiate Female Volleyball Players: An Experimental Study

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jan 20, 2026
Registry last updated
Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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