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OpenTrials
Completed

NCT Number: NCT06637956

The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery

Numerous preventive medications have been used to lessen the cardiovascular response to laryngoscopy and intubation. Though some advantages have been noted, most of these treatments have not been found to be completely satisfying. However, nitroglycerin is the most widely utilized medicine due to its fast effect, short half-life, and absence of sedative qualities.

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Key information

Conditions

Coronary Artery Bypass Grafting

Age range

35 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anesthesia, Rashid Latif Medical College

Lahore, Punjab Province, Pakistan

About this study

The circulatory system under compromise is less resilient to the effects of general anaesthesia. Inducing anaesthesia is a crucial step for cardiac patients because their impaired circulatory systems are less tolerant to depression. During coronary artery bypass grafting surgery, the primary objective of general anesthesia is to reduce sympathetic response to uncomfortable stimuli, including laryngoscopy, intubation, skin incision, sternal splitting, and spreading. A rise in blood pressure is one of the hemodynamic reactions that is typically associated with tracheal intubation and laryngoscopy. The impact of intra nasally delivered nitroglycerin on blood pressure response to laryngoscopy and intubation in patients having non-cardiac surgery is currently contentious; however, this study focus on coronary artery bypass grafting surgery patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both genders
  • Patients undergoing coronary artery bypass grafting surgery.
  • Patients aged 35-60 years.
  • Ejection Fraction between 50-60%.
  • American Society of Anesthesiologists Classification 3-4.

Exclusion criteria

  • Known hypersensitivity to nitroglycerin.
  • Anticipated difficult airway.
  • Emergency surgery.

Treatment and study plan

Nitroglycerin (NTG)

Drug

Received 1 mg of nitroglycerin intranasally two minutes prior to laryngoscopy and intubation

Primary outcomes

  1. Mean aterial pressure

    Time frame: 5 minutes post intubation

    Mean arterial pressure was measured prior to and after intubation

  2. Heart rate

    Time frame: 5 minutes post intubation

    Heart rate was measure prior to and after intubation

  3. Systolic blood pressure

    Time frame: 5 minutes post intubation

    Systolic blood pressure was measure prior to and after itubation

  4. Diastolic blood pressure

    Time frame: 5 minutes post intubation

    Diastolic blood pressure was measure prior to and after intubation

Sponsors and collaborators

Lead sponsor

Muhammad Aamir Latif

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Oct 15, 2024
Registry last updated
Oct 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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