Skip to main content
OpenTrials
Completed

NCT Number: NCT06793436

Serratus Anterior Plan Block (SAP) and Pectoralis Blocks (PECS I-II) After Open Heart Surgery

It was aimed to examine the effects of anterior chest wall blocks (PECS and SAP) performed for postoperative analgesia on pain scores assessed using the Visual Analog Scale (VAS), opioid consumption, duration of mechanical ventilation, time to first mobilization, ICU length of stay, postoperative nausea and vomiting (PONV), and block-related complications in adult patients undergoing coronary artery bypass grafting (CABG).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Postoperative Pain Coronary Artery Bypass Grafting Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Van Yuzuncu Yil University Faculty of Medicine Department of anesthesiology and reanimation

Van, Tuşba, 65080, Turkey (Türkiye)

About this study

This prospective randomized controlled trial evaluated the postoperative analgesic efficacy of ultrasound-guided serratus anterior plane (SAP) block and PECS II block in adult patients undergoing elective coronary artery bypass grafting (CABG). Eligible patients were randomized into three groups: SAP block, PECS II block, and a control group receiving standard systemic analgesia without regional block. The primary outcome was postoperative pain intensity assessed by Visual Analog Scale (VAS) scores at predefined post-extubation time points. Secondary outcomes included total opioid consumption within the first 24 postoperative hours, postoperative nausea and vomiting (PONV), and block-related complications. Exploratory recovery-related outcomes included mechanical ventilation duration, time to first mobilization, and ICU length of stay. Recovery-related outcomes were analyzed descriptively and considered exploratory because ICU clinicians were not blinded and important perioperative confounders were not systematically collected.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • Adult patients aged 20 years and older
  • ASA physical status II-IV
  • Scheduled for elective coronary artery bypass grafting (CABG)
  • Provided written informed consent

Exclusion criteria

  • Refusal to participate
  • Pregnancy
  • Presence of bleeding diathesis
  • Severe hepatic or renal failure

Treatment and study plan

Serratus Anterior Plane Block

Procedure

Ultrasound-guided serratus anterior plane (SAP) block performed with 30 mL of 0.25% bupivacaine.

PECS II block

Procedure

Ultrasound-guided PECS II block performed using a two-injection technique with a total of 30 mL of 0.25% bupivacaine.

Primary outcomes

  1. Postoperative pain intensity assessed using the Visual Analog Scale (VAS)

    Time frame: 4, 8, 12, and 24 hours after extubation

    Pain intensity will be assessed using the Visual Analog Scale (VAS). The VAS is a 10-centimeter scale where 0 cm = "no pain" and 10 cm = "worst imaginable pain"; higher scores indicate worse pain intensity. Assessments will be performed at 4, 8, 12, and 24 hours after extubation.

Secondary outcomes

  1. Postoperative nausea and vomiting (PONV) and block-related complications

    Time frame: Within 24 hours after surgery

    Postoperative adverse events including nausea, vomiting, and block-related complications will be recorded.

  2. Exploratory ICU length of stay

    Time frame: From ICU admission until ICU discharge, assessed up to 30 days

    Length of stay in the intensive care unit measured in hours from ICU admission

  3. Exploratory time to first mobilization

    Time frame: From ICU admission until first mobilization, assessed up to 7 days

    Time from ICU admission to first mobilization measured in hours

  4. Exploratory mechanical ventilation duration

    Time frame: From ICU admission until successful extubation, assessed up to 7 days

    Time from ICU admission to successful extubation

  5. Total opioid consumption within the first 24 postoperative hours

    Time frame: Cumulative opioid consumption assessed during the first 24 postoperative hours

    Total postoperative opioid consumption will be recorded as cumulative tramadol and pethidine doses administered within the first 24 postoperative hours and converted to intravenous morphine equivalents.

Sponsors and collaborators

Lead sponsor

Yuzuncu Yil University

Other

Registry information

Official study title

Serratus Anterior Plane and PECS II Blocks for Postoperative Analgesia After CABG: a Randomized Controlled Trial

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
Jan 27, 2025
Registry last updated
May 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.