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Completed

NCT Number: NCT02075333

The Effect of Ingesting or Rinsing Sucrose and Sucralose on Self-control, Cognitive Performance, and Blood Glucose

The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive performance, and blood glucose level.

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Key information

Conditions

Self-Control Behavior Blood Glucose Response Cognitive Performance Social Behavior

Age range

50 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Human Appetite Research Unit (University of Leeds)

Leeds, LS29JT, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI 18 - 29 kg/m2

Exclusion criteria

  • Dementia
  • Depression
  • Type 2 diabetes
  • Phenylketonuria
  • Intake of medication known to affect glucose metabolism
  • Fasting blood glucose > 7.8 mmol/L

Treatment and study plan

Ingestion of solution

Dietary Supplement

Participants will ingest the solution

Rinising of solution

Dietary Supplement

Participants rinse the solution in the oral cavity

Primary outcomes

  1. Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions

    Time frame: - 30, -15, - 5, + 5, + 10, + 20, + 30, + 40 minutes relative to rinsing or ingestion of sucrose or sucralose solutions (each separated by 7 days in crossover manner)

    Change from baseline in capillary blood glucose (assessed by lancet fingerprick and YSI blood glucose analyser)

Secondary outcomes

  1. Visual verbal learning and memory performance following self-control depletion

    Time frame: + 35 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)

    Visual verbal learning performance will be assessed by the Visual Verbal Learning Test (Rey, 1964) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution

  2. Attention switching performance following self-control depletion

    Time frame: + 20 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)

    Attention switching performance will be assessed by a switch task (Rogers and Monsell, 1995) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution

  3. Continuous blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions

    Time frame: 24 hours preceding and during ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in a crossover manner)

    A subgroup of 10 participants recruited into the study will be fitted with a continuous glucose monitoring device (CGMS, iPRO) the day preceding each of the test days to measure continuous interstitial blood glucose levels

Sponsors and collaborators

Lead sponsor

University of Leeds

Other

Collaborators

  • Sugar Nutrition, UK

Registry information

Official study title

The Effects of Ingesting or Rinsing Sucrose and Sucralose Solutions on Self-control, Cognitive Performance, and Blood Glucose Level

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Mar 3, 2014
Registry last updated
May 12, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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