Analysis of Psychoneuroimmunological Parameters of Health in Specific Population Groups in Slovakia

This study aims to investigate the links between psychological and biological immunity from the perspective of psychology, epidemiology, and immunology in a general population study sample as well as in a specific group of people in treatment for alcohol addiction.

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Key information

Conditions

Immunity Adverse Childhood Experience Anxiety Disorders Anxiety Symptoms Behavior Behavioral Symptoms Cytokine Levels Depression Depression Symptoms Fractures, Bone Fractures, Stress Mental Disorders Mindfulness Positive Thinking Problem Solving Psychological Adaptation Psychological Distress Resilience Self-Control Sense of Coherence Sense of Control Social Behavior Socio-economic Status Stress Stress Response Wounds and Injuries

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Comenius University Bratislava, Faculty of Arts, Bratislava, Slovakia

About this study

The study will explore the associations between the level of psychological immunity and the current psychological state of the participants, possible links between the level of psychological immunity in adulthood and adverse childhood experiences, and finally, the association between the psychological immunity and biological immunity expressed by the self- assessed perceived immune status and on a molecular level by quantity of cytokines and in a specific subgroup also by natural killer cells. All this will be studied in a sample of general population as well as in a specific group of people in treatment for alcohol addiction that was chosen based on the known adverse immune-related health effects of excessive alcohol consumption.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for 'General Slovak Population Sample':

Age between 18 - 50 years
Residency in the respective region for at least five years
Consent to participate in the study

Exclusion criteria

for 'General Slovak Population Sample':

Individuals younger than 18 or older than 50 years
Ongoing acute infectious disease on the day of testing
Eligible individuals who do not provide informed consent

Inclusion criteria

for the sample 'Individuals receiving inpatient treatment for alcohol addiction at the treatment facility':

Age between 18 - 50 years
Admission to treatment for alcohol addiction
Consent to participate in the study, Treatment completion

Exclusion criteria

for the sample 'Individuals receiving inpatient treatment for alcohol addiction at the treatment facility':

Individuals younger than 18 or older than 50 years
Eligible individuals who do not provide informed consent
Drop-out from alcohol addiction treatment

Treatment and study plan

Primary outcomes

The primary outcome measure is the correlation between psychological immunity, current health status and cytokine levels as indicators of biological immune function.

Time frame: At the time of study enrollment for Group 1, at the time of admission in treatment and after completion of 3 months of treatment for Group 2

The psychological instrument will consist of the Psychological immune competence inventory (PICI) to assess the psychological immunity.

Current health status will be assessed by the epidemiological instrument that will evaluate self-assessed immune status, overall, mental, and physical health, current long-term conditions, social, and economic status. Units of measure for the questionnaires is a score.

Cytokine secretion by immune cells will be tested using Bio-Plex ProTM Human Cytokine 17- plex assay according to the instructions of the manufacturer. For the analysis the blood plasma will be used. In each sample the following panel of cytokines will be analysed: G- CSF, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17A, MCP-1 (MCAF), MIP-1β, TNF-α. Cytokine units of measure are picograms per milliliter.

Sponsors and collaborators

Lead sponsor

Comenius University

Other

Collaborators

Slovak Academy of Sciences

Registry information

Acronym: APNIP

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2025
First posted: Jul 17, 2025
Registry last updated: Feb 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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