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NCT Number: NCT06854146

The Effect of Environmental Factors on Gastric Cancer Based on Macrogenome

The objectives of this study were to clarify how environmental factors such as air pollution affect the occurrence and development of gastric cancer; to identify patient-specific macrogenomic markers of gastric cancer; and to investigate the mechanism of gastric cancer development based on environmental factors and macrogenomic data.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Gastric Cancers Air Pollution Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Neoplasms Neoplasms by Site Stomach Diseases Stomach Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age ≥ 18 years;
  • patients with preoperative diagnosis of gastric cancer confirmed by pathologic biopsy;
  • no chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment;
  • willing to participate in the study and sign the informed consent form;
  • complete clinical data.

Exclusion criteria

  • concurrent primary malignant tumor other than gastric cancer;
  • patients with systemic diseases, such as severe cardiopulmonary;
  • insufficiency, that affect the choice of treatment plan;
  • not suitable for enrollment as assessed by the investigator;
  • incomplete clinical data.

Treatment and study plan

gastric cancer

Diagnostic Test

patients diagnosed with gastric cancer

healthy

Diagnostic Test

healthy participants

Primary outcomes

  1. Overall Survival (OS)

    Time frame: From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months

    Description: Time from diagnosis to death from any cause, measured via medical records and follow-up interviews.

    Unit: Months

Secondary outcomes

  1. Gut microbiome composition differences assessed by shotgun metagenomic sequencing

    Time frame: Tissue samples collected intraoperatively, sequencing completed within 1 week post-surgery.

    Measuring Tool: Shotgun metagenomic sequencing (Illumina NovaSeq 6000). Analysis Parameters: Alpha diversity (Shannon index); Beta diversity (Bray-Curtis dissimilarity); Differential abundance of bacterial species (ANCOM-BC).

    Unit: Relative abundance (%) / Diversity indices.

Sponsors and collaborators

Lead sponsor

Dong Peng

Other

Registry information

Official study title

Study on the Development and Prognosis of Gastric Cancer Based on Environmental Factors and Macrogenome

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Mar 3, 2025
Registry last updated
Mar 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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