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NCT Number: NCT06856382

The Association Between Microplastics and Macrogenomics and Metabolomics in Gastric Cancer

The aim of this study was to identify and quantify microplastics in blood, stool, and tumor surgical specimens from gastric cancer patients by analyzing the nature, type, and abundance of microplastics using laser direct infrared (LDIR) spectroscopy, scanning electron microscopy (SEM), and pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS). Meanwhile, combining macro-genomic and metabolomic techniques to explore the association between microplastics and host microbiota and metabolic profiles, and to reveal the potential effects of microplastics on gastric cancer incidence and development will provide new insights into the relationship between microplastic contamination and gastric cancer, as well as an important scientific basis for future public health strategies and cancer prevention and control measures.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Gastric Cancers Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Neoplasms Neoplasms by Site Stomach Diseases Stomach Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

About this study

This This study is planned to collect blood, cancer and paracancer tissues, and stool samples from 20 patients with gastric cancer, 2 gastric cancer tissues (at least 1cm^3 each), 2 gastric paracancer tissues (at least 1cm^3 each), 2 venous bloods (5ml each), and 1 stool (at least 10g each) from each patient. Samples will be collected from December 2024 through November 2025, with an expected total of 140 samples. Sample collection, transportation, and storage are described in IV.2. & 3. Samples will be analyzed for the type, nature, and abundance of microplastics by Laser Direct Infrared Spectroscopy (LDIR), Scanning Electron Microscopy (SEM), and Pyrolysis-Gas Chromatography-Mass Spectrometry (Py-GC/MS), which is expected to detect microplastics such as polyamides, polyethylene terephthalate (PET), and polyvinyl chloride (PVC). At the same time, blood and tissue samples will be metabolomically assayed using NNR-IVD technology and macro-genomic sequencing will be performed to explore potential associations between microplastics and microbiota and metabolic pathways in gastric cancer patients. By analyzing the distribution characteristics of microplastics in gastric cancer patients and their relationship with microbial communities and metabolic pathways, this study will reveal the impact of microplastics on the tumor microenvironment and further understand their role in gastric cancer development and progression.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age ≥18 years old;
  • diagnosed with gastric cancer by pathology before surgery and not receiving chemotherapy, radiotherapy or immunotherapy;
  • no history of other gastrointestinal diseases;
  • complete clinical data and basic information;
  • willing to participate in this study and sign an informed consent form.

Exclusion criteria

  • Patients receiving neoadjuvant radiotherapy or chemotherapy;
  • patients with other malignant tumors other than gastric cancer;
  • patients with incomplete or unclear pathological data;
  • individuals who are not willing to participate in the study.

Treatment and study plan

gastric cancer

Diagnostic Test

Patients diagnosed with gastric cancer by pathological biopsy.

Primary outcomes

  1. Types of microplastics in gastric cancerous and paracancerous tissues (categorical measure)

    Time frame: The date of microplastics testing, assessed up to 1 week after surgery.

    Polymer types of microplastics in gastric tissues Time Frame: Intraoperative sampling Measuring tool: μ-FTIR spectroscopy Unit: Categorical classification (e.g., polyethylene, polypropylene, etc.)

Secondary outcomes

  1. Physical-chemical properties of microplastics in gastric cancerous and paracancerous tissues (continuous measure)

    Time frame: The date of microplastics testing, assessed up to 1 week after surgery.

    Morphological characteristics of microplastics in gastric tissues Time Frame: Intraoperative sampling Measuring tool: Optical microscopy Unit: Size (μm), shape distribution (%)

  2. Abundance of microplastics in gastric cancerous and paracancerous tissues (count/particles per gram)

    Time frame: The date of microplastics testing, assessed up to 1 week after surgery.

    Microplastic abundance in gastric tissues Time Frame: Intraoperative sampling Measuring tool: Gravimetric analysis/particle counting Unit: Particles per gram tissue

Sponsors and collaborators

Lead sponsor

Dong Peng

Other

Registry information

Official study title

Identification of Paraneoplastic and Intratumor Microplastics in Gastric Cancer and Their Association Analysis With Macrogenomics and Metabolomics

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Mar 4, 2025
Registry last updated
Mar 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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