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NCT Number: NCT04781439

The Effect of Early Switching From Intravenous to Oral Antibiotics Therapy

To date, many studies showed the great benefits of switching from IV to PO antibiotics in some infectious diseases, especially skin and soft tissue, urinary tract, respiratory tract, gallbladder, and biliary tract infection. Higher level of evidence is necessary to confirm the benefit of early switching protocol in infectious condition management. Therefore, we conducted a clinical trial to investigate the effectiveness and cost of IV-to-PO antibiotic switch therapy in some surgical infection conditions.

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Key information

Conditions

Skin and Subcutaneous Tissue Infection Cellulitis Connective Tissue Diseases Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Skin Diseases, Infectious Skin and Connective Tissue Diseases Suppuration

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gia Dinh people hospital

Ho Chi Minh City, 700000, Vietnam

About this study

Introduction: The benefit of early switching from intravenous (IV) to oral (PO)was raising from the last decade. This randomized clinical trial was to evaluate the effect of early switching from IV to PO antibiotics on the outcome of surgical patients at a public hospital.

Methods: Patients admitted for a therapeutic antibiotic to orthopedic and general surgery conditions were randomly assigned to three groups: control (non-switching), early switching (within 48-72 hours), and late switching (after 72 hours). The rate of effectiveness of each arm, length of hospital stay, length of IV antibiotics, and cost were recorded prospectively.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • on the second day of IV antibiotic
  • no difficulties on taking oral medication
  • clinical improvement

Exclusion criteria

  • n/a

Treatment and study plan

IV-to-PO conversion of antibiotics

Procedure

IV-to-PO switching of antibiotics treatment

Primary outcomes

  1. rate of effectiveness

    Time frame: 3 months

    rate of effectiveness of the infection treatment

Secondary outcomes

  1. length of hospital stay

    Time frame: 3 months

    length of hospital stay after starting the antibiotic treatment

  2. length of IV antibiotics

    Time frame: 3 months

    length of IV antibiotics usage

  3. cost of treatment

    Time frame: 3 months

    cost of antibiotics

Sponsors and collaborators

Lead sponsor

Gia Dinh People Hospital

Other

Registry information

Official study title

The Effect of Early Switching From Intravenous to Oral Antibiotics Therapy: a Randomized Control Trial

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Mar 4, 2021
Registry last updated
Mar 4, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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