Skip to main content
OpenTrials
Completed

NCT Number: NCT02594969

The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis

The goal is this study is to investigate the effects of dilute bleach on the skin of subjects with atopic dermatitis and those with healthy skin. The second goal is to evaluate the effects of different moisturizers on the skin barrier of subjects with and without atopic dermatitis. The investigators hypothesize that the bleach bath will increase the skin pH, decrease the skin hydration, and increase skin water loss in all study subjects. Secondly, the investigators hypothesize that moisturizers with the lowest pH and the highest water to oil ratio will result in improved skin barrier function. Furthermore, the investigators believe there will be a greater improvement in patients with atopic dermatitis.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Atopic Dermatitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dermatitis Dermatitis, Atopic Genetic Diseases, Inborn Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Skin Diseases Skin Diseases, Eczematous Skin Diseases, Genetic Skin and Connective Tissue Diseases

Age range

8 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UC Davis Department of Dermatology

Sacramento, California, 95816, United States

About this study

The study has two main parts. Subjects in both groups will have one forearm in a dilute bleach bath and the other arm in a water bath for 10 minutes. The change in skin will be measured using different painless devices. The second part of the study involves application of 4 various moisturizers. The change in skin will be measured over a period of time using the non-invasive devices.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 8 years to 65 years
  • Has been diagnosed with atopic dermatitis by a board-certified dermatologist at UC Davis
  • Subject/parents/legal guardians able to read and comprehend the study procedure and consent forms.

Exclusion criteria

  • Those who are pregnant, prisoners, or cognitively impaired
  • Those who do not fit the inclusion criteria

Treatment and study plan

Bleach Bath and Moisturizers

Other

All subjects will have one forearm in a bleach bath and the other forearm in a water bath for 10 minutes. Following the bath, skin barrier function will be evaluated. Secondly, moisturizers will be applied to the arms and the skin barrier will be evaluated overtime.

Other names: Hypochlorite Solution

Primary outcomes

  1. Change in transepidermal water loss post-bath immersion

    Time frame: 10 minutes post-bath immersion

    Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in transepidermal water loss after 10 minutes of bath immersion.

Secondary outcomes

  1. Change in transepidermal water loss after moisturizer application

    Time frame: up to 60 minutes post-moisturizer application

    Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in transepidermal water loss to 60 minutes post-application..

  2. Change in skin hydration after moisturizer application

    Time frame: up to 60 minutes post-moisturizer application

    Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in skin hydration up to 60 minutes post-application..

  3. Change in skin pH after moisturizer application

    Time frame: up to 60 minutes post-moisturizer application

    Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in skin pH up to 60 minutes post-application..

  4. Change in skin hydration post-bath immersion

    Time frame: 10 minutes post-bath immersion

    Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in skin hydration after 10 minutes of bath immersion.

  5. Change in skin pH post-bath immersion

    Time frame: 10 minutes post-bath immersion

    Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in skin pH after 10 minutes of bath immersion.

Sponsors and collaborators

Lead sponsor

University of California, Davis

Other

Registry information

Acronym: AD

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Nov 3, 2015
Registry last updated
May 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.