The Effect of Continuous Management of Suction Cuff Pressure and Subglottic Irrigation Suction on Preventing VALRI Study

Inclusion criteria

• Age ≥ 18 years;
• Undergoing endotracheal intubation or tracheostomy;
• Expected duration of mechanical ventilation exceeding 72 hours;
• Presence of one or more high-risk factors for reflux/aspiration: recurrent laryngeal nerve injury, cerebral infarction/cerebral hemorrhage (new or pre-existing swallowing dysfunction), cranial surgery/traumatic brain injury (TBI), neuromuscular junction disorders (e.g., myasthenia gravis, muscular dystrophy, Parkinson's disease, or other conditions that weaken swallowing muscle strength and coordination), continuous use of muscle relaxants for ≥ 48 hours during mechanical ventilation, ICU-acquired myopathy, ICU-acquired weakness, gastroparesis (gastric residual volume > 500 mL/6 hours), or impaired consciousness;
• Voluntary participation in the study by the subject or their legal representative, with signed informed consent.

Exclusion criteria

• Expected duration of mechanical ventilation less than 48 hours;
• Pregnant or breastfeeding women;
• Patients with tracheoesophageal or bronchopleural fistula;
• Difficult intubation (more than three attempts) or patients with reflux/aspiration during intubation (with lung injury and secondary pulmonary infection);
• Patients with irreversible disease, end-stage conditions, or those expected to die in the near future;
• Patients already diagnosed with ventilator-associated pneumonia (VAP), i.e., excluding hospital-acquired pneumonia;
• Patients participating in other clinical trials that are expected to influence the results of this study;
• Patients deemed unsuitable for inclusion in the study by the investigator.