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NCT Number: NCT07688057

Comparison of Green Tea, White Tea, and Chlorhexidine Oral Care for Prevention of Ventilator-Associated Pneumonia

This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP) in intensive care unit patients receiving mechanical ventilation (MV)

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Recep Tayyip Erdogan University Research and Training Hospital

Rize, Merkez, 53020, Turkey (Türkiye)

About this study

This prospective controlled interventional study included 63 mechanically ventilated adult intensive care unit patients. Participants were assigned to one of three oral care groups receiving chlorhexidine (CHX), green tea, or white tea according to the study protocol. Oral health was assessed using the Bedside Oral Examination (BOE) guide on days 1, 3, and 7. The primary objective was to compare the incidence of ventilator-associated pneumonia (VAP) among the study groups. Secondary outcomes included changes in oral health status and functional oral assessment during follow-up.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged over 18 years
  • With no known allergies
  • Receiving invasive mechanical ventilator support
  • With a negative endotracheal aspirate culture on the day of ICU admission
  • Within the first 24 hours of mechanical ventilator support
  • Patients whose relatives agreed to participate in the study

Exclusion criteria

  • Patients with positive endotracheal aspirate cultures within the first 48 hours of intensive care admission,
  • Patients undergoing radiotherapy or chemotherapy,
  • Patients with contraindications for oral care,
  • Patients with a platelet count below 30,000/mm³,
  • Patients who cannot be positioned appropriately,
  • Patients with agitation severe enough to prevent the procedure from being performed

Treatment and study plan

Clorhexidine group

Procedure

oral care using clorhexidine solution, green tea and white tea

Other names: clorhexidine

Green Tea group

Procedure

Participants received oral care using green tea according to the study protocol.

Other names: green tea

white tea group

Procedure

Participants received oral care using white tea according to the study protocol.

Primary outcomes

  1. ventilator associated pneumonia devolopment

    Time frame: 7 days

    Comparison of the incidence of ventilator-associated pneumonia among the chlorhexidine, green tea, and white tea oral care groups.

Sponsors and collaborators

Lead sponsor

Recep Tayyip Erdogan University

Other

Registry information

Official study title

Comparison of Chlorhexidine, Green Tea, and White Tea Oral Care for the Prevention of Ventilator- Associated Pneumonia in Mechanically Ventilated Patients

Acronym: TEA-VAP

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Jul 7, 2026
Registry last updated
Jul 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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