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Completed

NCT Number: NCT00125866

The Effect of Cocoa Flavonoids on Blood Pressure

The purpose of this study is to compare the effects on blood pressure of a daily intake of a flavonoid-rich cocoa drink with that of the same drink from which the flavonoids have been largely extracted.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Imperial College London

Paddington, London, W2 1PG, United Kingdom

About this study

Flavonoids are natural substances found in fruits and vegetables, tea and red wine. The investigators know that people who eat a diet rich in these foods are less likely to have heart disease. This, in part, may be due to the blood pressure lowering effect of flavonoids. Cocoa beans are a rich natural source of flavonoids. Unfortunately when cocoa is made into chocolate most of the flavonoids are destroyed. The aim of this study is to find out the effect of cocoa flavonoids on blood pressure after 12 weeks of daily consumption of a specially prepared chocolate drink that is rich in flavonoids.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males or females of any age.
  • Diagnosis of hypertension and on antihypertensive treatment.
  • Stable blood pressure that has reached the British Hypertension Society (BHS) audit standard (<150/90mmHg).

Exclusion criteria

  • Participation in another clinical trial.
  • Any reason to suspect that the patient will not comply with drinking a chocolate beverage every day for the trial duration.

Treatment and study plan

Flavonoid rich or flavonoid depleted chocolate drink

Behavioral

Primary outcomes

  1. Difference in mean 24 hour ambulatory blood pressure

Secondary outcomes

  1. Difference in cholesterol

  2. Difference in glucose

  3. Difference in insulin

  4. Difference in echocardiogram

  5. Difference in pulse wave velocity

Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Collaborators

  • MasterFoods

Registry information

Official study title

The Effect of Cocoa Polyphenols on Various Cardiovascular Measurements Including Blood Pressure

Important dates

Study start
2005
Study completion
2006
First posted
Aug 2, 2005
Registry last updated
May 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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