The Effect of Bathing and Moisturizers on Skin Hydration in Atopic Dermatitis: an in Vivo Study

Inclusion criteria

• male or female;
• Age range 18-45 years;
• Subjects have history and physical findings consistent with mild to moderate AD with SCORAD score ≤ 40;
• Stop using some drugs such as oral corticosteroid for at least 4 weeks, topical corticosteroid and calcineurin inhibitor for at least 2 weeks, food supplement such as evening primrose oil, wheat extract Flax seed oil sunflowerseed oil, borage oil and fish oil for at least 3 months;
• Subjects who have signed the written informed consent.

Exclusion criteria

• Subjects who have medical histories such as zinc or essential fatty acid deficiency, end stage renal disease, hypothyroidism, human immunodeficiency virus (HIV), malignancies, obstructive biliary disease, diabetes mellitus and in those who have had radiation or other medical histories that may interfere the outcome;
• Subjects who ingest drugs that could interfere with the study results such as diuretics, antiandrogens, lipid reducing agents, isotretinoin cimetidine;
• Subjects cannot enroll until the end of the project;
• Subjects who have allergy to any ingredient in the moisturizer or cleanser that will be used in the protocol;
• Pregnant woman or lactating woman.