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NCT Number: NCT07389226

The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults

This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

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Key information

Conditions

Kidney Stones Calculi Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Calculi Kidney Diseases Male Urogenital Diseases Nephrolithiasis Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Urinary Calculi Urine Specimen Collection Urogenital Diseases Urolithiasis Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

The primary objective of this study is to determine whether a two-week course of daily ACV supplementation significantly changes an individual's urine chemistry. The investigators will study this in healthy individuals and individuals with kidney stones.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Controls: Adults above the age of 18.
  • Kidney stone patients: Adults above the age of 18.
  • History of majority (>50%) calcium oxalate kidney stones

Exclusion criteria

  • Anyone with a history of calcium phosphate stones (>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (<30 days), or recurrent urinary tract infections.
  • Any individual who has had ACV outside of normal consumption in the prior month will be excluded.
  • Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded.
  • Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.

Treatment and study plan

apple cider vinegar

Dietary Supplement

Goli Apple Cider Vinegar gummies

Primary outcomes

  1. Measure changes in citrate in urine.

    Time frame: From Enrollment to 2 weeks

    to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

  2. Measure changes in Urine PH

    Time frame: From enrollment to 2 weeks

    to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

  3. Measure changes in calcium in urine.

    Time frame: from enrollment to 2 weeks

    to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

  4. Measure changes in calcium oxalate in urine

    Time frame: From Enrollment to 2 weeks

    to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

Study contacts

Contact information is provided by the study sponsor or research team.

Luke Reynolds

CONTACT

[email protected]

7137926105

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Feb 5, 2026
Registry last updated
Jul 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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