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Completed

NCT Number: NCT05588986

The Effect of Antenatal Corticosteroid on Umbilical Artery Doppler Velocimetry in IUGR

The purpose of this study is to evaluate the effect of antenatal corticosteroid administration on umbilical artery Doppler velocimetry measurements in pregnancies complicated by IUGR.

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Key information

Conditions

Intrauterine Growth Restriction Congenital, Hereditary, and Neonatal Diseases and Abnormalities Female Urogenital Diseases and Pregnancy Complications Fetal Diseases Fetal Growth Retardation Growth Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Pregnancy Complications Urogenital Diseases

Age range

18 year–49 year

Sex eligibility

Female

Study type

Observational

Primary location

Merve Demir

Kocaeli, 41000, Turkey (Türkiye)

About this study

This study was conducted with pregnant women who were likely to have preterm birth and were treated with antenatal corticosteroids. Betamethasone was used as an antenatal corticosteroid. UA Doppler measurements (PI, S/D ratio, RI) before antenatal corticosteroid administration and 24 and 48 hours after the last dose of corticosteroid administration were evaluated in pregnant groups complicated with IUGR and uncomplicated with IUGR and compared with each other.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

pregnant women who were likely to have preterm delivery and were treated with antenatal corticosteroids.

Exclusion criteria

Pregnant women who had complicated pregnancy with fetal anomaly, who had multiple pregnancies, who left their pregnancy follow-up unfinished, and those under 18 years of age were excluded from the study.

Treatment and study plan

Ultrasonography

Other

Umbilical artery Doppler evaluation by ultrasonography just before the first dose of antenatal corticosteroid, 24 hours and 48 hours after the last dose.

Primary outcomes

  1. systolic:diastolic ratio (S/D ratio)

    Time frame: 2018-2019

    Peak systolic velocity/end diastolic velocity

  2. pulsatility index (PI)

    Time frame: 2018-2019

    Pulsatility Index (PI) = (Peak systolic velocity - end diastolic velocity)/(time averaged maximum velocity)

  3. Resistive Index (RI)

    Time frame: 2018-2019

    Resistive Index (RI) = (Peak systolic velocity - end diastolic velocity)/(peak systolic velocity)

Sponsors and collaborators

Lead sponsor

Merve Demir

Other

Collaborators

  • Marmara University

Registry information

Official study title

The Effect of Antenatal Corticosteroid Administration on Umbilical Artery Doppler Velocimetry in Pregnant Women Complicated With IUGR

Important dates

Study start
2018
Primary completion
2018
Study completion
2019
First posted
Oct 20, 2022
Registry last updated
Aug 2, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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