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Completed

NCT Number: NCT07299396

THE EFFECT OF ALVEOLAR RECRUITMENT MANOEUVRE ON INTRAOPERATIVE HAEMODYNAMICS

Alveolar recruitment manoeuvre plays a key role in the prevention of atelectasis. In addition, it affects haemodynamic parameters. This study aims to investigate the effects of RM on haemodynamic parameters using minimally invasive monitoring techniques.

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Key information

Age range

18 year–70 year

Sex eligibility

Female

Study type

Observational

Primary location

Balikesir University

Balıkesir, 10145, Turkey (Türkiye)

About this study

During laparoscopic hysterectomy, pneumoperitoneum is created with carbon dioxide (CO₂) to provide surgical field of view and the patient is placed in Trendelenburg position. This increases intrathoracic pressure, decreases lung compliance and increases the risk of atelectasis. Therefore, lung protective ventilation strategies such as alveolar recruitment manoeuvre (RM), individualised PEEP application and low tidal volume are recommended. RM aims to increase lung compliance and prevent atelectasis by reopening collapsed alveoli. However, changes in haemodynamic parameters, especially mean arterial pressure and cardiac output, may occur during RM. In addition to standard monitoring for the management of these changes, haemodynamic evaluation can be performed with minimally invasive methods such as arterial waveform analysis. In this study, we aimed to evaluate the effects of RM applied during laparoscopic hysterectomy on intraoperative haemodynamic parameters using arterial waveform analysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA Class 1-2 patients 18-70 years old

Exclusion criteria

  • <18 y, BMI>40
  • Patients receiving invasive mechanical ventilator support in the last 1 month
  • Patients who have received chemotherapy or radiotherapy in the last 2 months
  • Those with severe lung disease (COPD, asthma, pulmonary infection, bronchiectasis, previous need for non-invasive mechanical ventilation, oxygen therapy or steroid therapy for acute attack)
  • Known severe pulmonary hypertension
  • Patient refusal to participate in the study
  • Intracranial tumour
  • Haemodynamic instability
  • Shock
  • Neuromuscular disease
  • Pathologies causing increased intracranial and intraocular pressure
  • Atrial fibrillation

Treatment and study plan

Primary outcomes

  1. Effect of RM on heart rate (in bpm)

    Time frame: perioperatively

    measurement of heart rate in bpm

  2. Effect of RM on pressure mmHg

    Time frame: perioperatively

    blood pressure measurement in mmmercury

  3. Effect of RM on Cardiac index(CI)

    Time frame: intraoperatively

    Cardiac Index measurement via an arterial cannula as l/min/m2

  4. Effect of RM on stroke volume index(SVI)

    Time frame: intraoperatively

    SVI measurement via arterial cannula as L/min/m2

  5. Effect of RM on pulse pressure variablity(PPV)

    Time frame: intraoperatively

    pulse pressure variability measured by finger probe as cm/s

  6. Effect of RM on systemic vascular resistance index(SVRI)

    Time frame: intraoperatively

    systemic vascular resistance index(SVRI) measurement via arterial cannula as L/min/m2

  7. Effect of RM on cardiac power index(CPI)

    Time frame: intraoperatively

    cardiac power index(CPI) measurement via arterial line as ml/min/m2

Secondary outcomes

  1. Effect of RM on Compliance

    Time frame: intraoperatively

    measurement of dynamic compliance by Ventilator as Cdyn

  2. Effect of RM on Oxygenation

    Time frame: İntraoperatively

    measurement of oxygenation via obtaining partial blood oxygene pressure via arterial blood sample pulse oxymeter as %

  3. Postoperative pulmonary comlications (infection, bronchospasm, pleural effusion, atelectasis, respiratory failure)

    Time frame: postoperative day 1 and 3

    assessment of pulmonary complications

Sponsors and collaborators

Lead sponsor

Balikesir University

Other

Registry information

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Dec 23, 2025
Registry last updated
Dec 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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