Skip to main content
OpenTrials
Completed

NCT Number: NCT01738906

The Effect of Alcohol on Food Reward

Rationale

It has been shown in several studies that alcohol increases subsequent food intake. However, moderate alcohol consumption has no clear effects on hunger and satiety hormones. In the Western world, where palatable food is highly available, food reward may play an important role in food intake. Alcohol consumption is known to stimulate neurotransmitters important for food reward and may therefore stimulate the reward response on a subsequent meal. This may lead to higher food consumption than when no alcohol is consumed. It is hypothesized that the reward response of food or beverages can already be generated when food or beverages are sensed in the mouth, because oral nutrient sensing is known to induce a satiety response (i.e. the cephalic phase response). Moreover, taste buds directly signal brain areas closely connected to the reward areas in the brain.

Primary objective

* To determine whether moderate alcohol consumption influences subsequent food reward, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to reward.

Secondary objectives

* To determine whether food reward is different when food is consumed than when food is sensed in the mouth, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to food reward. * To determine whether moderate alcohol consumption influences subsequent food reward differently when food is consumed than when food is sensed in the mouth, as measured by questionnaires on food 'wanting' and food 'liking', and salivary and blood parameters related to food reward.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

25 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre for Human Drug Research (CHDR)

Leiden, South Holland, 2333 CL, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Caucasian men;
  • Age 25-50 years on the day of the screening;
  • Body Mass Index (BMI) of 20-25 kg/m2;
  • Body weight of 60-100 kg;
  • Able to read, write and fully understand the Dutch language, and
  • Able to participate int he sudy, willing to give written informed consent and to comply with the study procedures and restrictions.

Exclusion criteria

  • Above average score (>2.26) on the restrained scale of the Dutch Eating Behaviour Questionnaire;
  • Alcohol consumption <6 and >20 standard glasses/week;
  • Not having regular and normal Dutch eating habits;
  • Not having a normal day/night rhythm;
  • Smoking, or stopped with smoking <3 months prior to start of the study;
  • Using drugs, or stopped using drugs <3 months prior to start of the study;
  • Having a (family) history of alcohol or drug related problems;
  • Reported slimming or being on a medically described diet;
  • Having a vegan, vegetarian or macrobiotic lifestyle;
  • Loss of blood outside the limits of Sanquin within 3 months prior to screening;
  • Participation in a clinical trial within 3 months prior to the start of this study or more than 4 times a year;
  • Having a food allergy, sensitivity or disliking one of the foods used in the study;
  • Reported unexplained weight loss or gain of >4 kg in the month prior to the screening;
  • Inappropriate veins for cannula insertion;
  • Not having a general practitioner or health insurance;
  • Having a history of medical or surgical events or disease that may significantly affect the study outcome, particularly physiological disorders, metabolic or endocrine disease and gastrointestinal disorders; and/or
  • Any condition which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol.

Treatment and study plan

Orange juice

Other

Other names: Orange Juice (Appelsientje)

maltodextrin

Other

Other names: Fantomalt maltodextrin (energy powder), Nutricia

Vodka

Other

Other names: Smirnoff Vodka

butter cake MSF

Other

chewing on 40 gram cake for 6 minutes and before swallowing expectorating the bolus in cup.

Other names: cake modified sham feeding

butter cake consumption

Other

chewing for 6 min on 40 gram cake and then swallow it.

Other names: cake consumption

Primary outcomes

  1. Explicit food 'wanting'

    Time frame: up to 75 minutes

    Questionnaire measuring food 'wanting' explicitly with the question: "How much do you want to eat at this moment?" This is scored on a visual analogue scale ranging from 0-100.

  2. Implicit food 'wanting' for different food categories

    Time frame: up to 30 minutes

    Computer task measuring food 'wanting' implicitly for different food categories. This is a forced choice task in which subjects have to choose as quick and precise the food product they want to eat most at that moment.

  3. explicit food 'wanting' for different food categories

    Time frame: up to 30 minutes

    Questionnaire measuring food wanting explicitly for different food categories on a visual analogue scale (ranging 0-100).

  4. explicit food 'liking' for different food categories

    Time frame: up to 30 minutes

    Questionnaire measuring food 'liking' for different food categories on a visual analogue scale (ranging 0-100).

Sponsors and collaborators

Lead sponsor

Henk FJ Hendriks

Other

Collaborators

  • Foundation for Alcohol Research (SAR), The Netherlands
  • Ministry of Economic Affairs, The Netherlands

Registry information

Official study title

The Effect of Moderate Alcohol Consumption on Subsequent Food Reward

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Nov 30, 2012
Registry last updated
Jan 3, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.