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Completed

NCT Number: NCT03231215

The Effect of Adding Dexamethasone to Epidural Bupivacaine for Total Knee Replacement Surgery

The purpose of this study was to evaluate the efficacy of dexamethasone when added to epidural bupivacaine on the duration of postoperative analgesia in patients underwent total knee replacement surgery.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Fifty patients underwent total knee replacement were included in the study. The patients (11 male and 39 female) were classified into two equal groups:- The patients received 15 mL plain bupivacaine + 2 mL (BS), or 8 mg dexamethasone (BD). The total volume injected in both groups was 17 ml.

Postoperative records:

  • Pain score (NRS) at base line, then every 4 hrs for 24 hrs.
  • Frequency of rescue analgesia.
  • Postoperative side effects like nausea, vomiting, and over sedation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for total knee replacement surgery.
  • ASA Physical status I,II,III.

Exclusion criteria

  • Patients' refusal.
  • Uncooperative patients / Not able to understand pain assessment test.
  • Patients with history of allergy to the used drugs.
  • Significant liver disease.
  • Pregnancy.
  • Any contraindication for epidural anesthesia
  • Failed technique.

Treatment and study plan

Dexamethasone

Drug

dexamethasone + plain Bupivacaine injected epidurally.

Other names: Decadrone

Primary outcomes

  1. duration of postoperative analgesia (NRS)

    Time frame: 24 hrs postoperative

    first patient request for analgesia or NRS 4 or more

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jul 27, 2017
Registry last updated
Aug 3, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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