The Drug-Drug Interaction of SHR4640, Febuxostat and Colchicine in Patients With Gout

Inclusion criteria

• Subject has a body mass index ≥18.5 and ≤30 kg/m2;
• Screening sUA value ≥8mg/dl;
• Subject has no clinically relevant abnormalities in vital signs, ECG, physical examination，imaging examination or safety laboratory values.

Exclusion criteria

• Subject known or suspected of being sensitive to the study drugs or its ingredient；
• sCr>ULN;
• History of kidney stones or screening kidney stones by B-ultrasound；
• History of malignancy within 5 years；
• History of xanthinuria；
• Donated blood（≥400ml）within 3 months prior to screening or received transfusion of blood。