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Active, Not Recruiting

NCT Number: NCT07679737

The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation

CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional cardiac arrest care.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Out of Hospital Cardiac Arrest Cardiovascular Diseases Extracorporeal Cardiopulmonary Resuscitation Heart Arrest Heart Diseases Out-of-Hospital Cardiac Arrest

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Monash University

Melbourne, Victoria, Australia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Witnessed cardiac arrest
  • Bystander CPR
  • Refractory cardiac arrest (failure to achieve sustained ROSC >20 minutes)
  • Initial cardiac rhythm VF, VT or PEA
  • Within the hours of prehospital ECPR service operation

Exclusion criteria

  • Initial cardiac rhythm asystole
  • ROSC with sustained recovery
  • Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest
  • Evidence of/suspected end-stage disease:
  • severe disability impairing activities of daily living
  • end-stage organ disease - cardiac, liver, lung, renal
  • other life-limiting diseases, e.g. malignancy, terminal illness
  • advance health care directive
  • Time periods of advanced public health restrictions in Victoria and NSW due to COVID-19

Treatment and study plan

Extracorporeal cardiopulmonary resuscitation

Other

The Intervention being evaluated is the initiation of extracorporeal cardiopulmonary resuscitation (ECPR) at the scene, in addition to conventional cardiac arrest care.

Other names: Extracorporeal Cardiopulmonary Resuscitation (ECPR), Prehospital ECPR, Scene based ECPR

Primary outcomes

  1. Survival to hospital discharge

    Time frame: From meeting full eligibility criteria until the date/time of death or hospital discharge, assessed up to 180 days

Secondary outcomes

  1. Low flow time

    Time frame: time from onset of arrest to time of ECPR flow, or time of death

  2. ICU length of stay

    Time frame: From the date/time of ICU admission until the date/time of ICU discharge/death, assessed up to 180 days

  3. Mechanical ventilation days

    Time frame: From date/time of mechanical ventilation commencement until date/time of liberation from mechanical ventilation assessed up to 180 days

  4. ECMO complications

    Time frame: From the date/time of commencement of ECMO support until 1 week following the date/time of cessation of ECMO support

  5. Rates of organ and tissue donation in non-survivors

    Time frame: In the 48hours following date/time of death

Sponsors and collaborators

Lead sponsor

Australian and New Zealand Intensive Care Research Centre

Other

Registry information

Official study title

The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation (CHEER4TTE)

Acronym: CHEER4TTE

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 1, 2026
Registry last updated
Jul 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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