Skeletal Muscle Mass on Prognosis and Recovery in Clinical Trial

The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction model for patients who have experienced cardiac arrest and undergone resuscitation. The model will be validated using multicenter registry data and medical imaging. Furthermore, a clinical trial involving core muscle rehabilitation for post-resuscitation patients will be conducted to evaluate both short-term and long-term outcomes, aiming to comprehensively understand the impact of muscle mass on the prognosis of patients after cardiac arrest.

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Key information

Conditions

Out of Hospital Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases Inhospital Cardiac Arrest Out-of-Hospital Cardiac Arrest

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Emergency Medicine, National Taiwan University Hospital

Taipei, 100, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Non-traumatic adult patients who experienced sudden cardiac arrest
Achieved sustained return of spontaneous circulation (ROSC) for more than five minutes following successful resuscitation
Admitted to the ICU
Survived beyond 72 hours without successful weaning from mechanical ventilation

Exclusion criteria

Age under 18 years
Pregnancy
Expected to be weaned from mechanical ventilation within 48 hours
Terminal-stage cancer or unwillingness to receive aggressive treatment
Unavailability of ICU care due to overcrowding in the emergency intensive care unit
Refusal to participate in the study by the patient or family members
Presence of an implanted pacemaker or defibrillator
Open wounds, severe edema, or deep vein thrombosis in the lower limbs
Pre-arrest status limited to wheelchair use or bedridden, unable to ambulate

Treatment and study plan

Enhanced Rehabilitation Program

Behavioral

Participants in the intervention group receive an enhanced rehabilitation program, including muscular electrical stimulation, guided active rehabilitation sessions, and structured physical engagement during periods of consciousness. The intervention is designed to promote functional improvement in post-cardiac arrest patients.

Primary outcomes

skeletal muscle mass

Time frame: 21 days

Muscle changes were measured weekly using a handheld ultrasound.

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

Comprehensive Interpretation of the Importance of Skeletal Muscle Mass on Prognosis and Recovery in Cardiac Arrest Survivors: From Machine Learning to Clinical Trial

Important dates

Study start: 2025
Primary completion: 2028
Study completion: 2028
First posted: Jun 24, 2025
Registry last updated: Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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