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NCT Number: NCT06980779

The Correlation of Clinical and Ultrasonographic Findings in Dorsoradial Wrist Pain Patients: Cross Sectional Study

This study aims to investigate the correlation between ultrasonographic and clinical findings in dorsoradial wrist pain. There are several etiologies for dorsoradial wrist pain, including carpometacarpal joint arthritis, De Quervain's tenosynovitis, proximal and distal intersection syndrome, Wartenberg syndrome, and ganglion cysts. In these clinical scenarios, certain physical examination tests are utilized, such as the Finkelstein test for De Quervain's tenosynovitis; however, this test may also yield positive results in cases of severe joint arthritis. Ultrasonography is proposed as a complementary tool for differential diagnosis. The investigators aim to examine the correlation between clinical test results and ultrasonographic parameters such as tendon thickness in the first extensor compartment, carpometacarpal joint synovitis, cortical irregularities, and the presence of osteophytes. Functional status will be assessed using the QuickDASH and FIHOA questionnaires.

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Key information

Conditions

Carpometacarpal (CMC) Joint Arthritis Capillary Malformations, Congenital, 1 Connective Tissue Diseases Cysts De Quervain Disease Ganglion Cyst Ganglion Cysts Mononeuropathies Mucinoses Muscular Diseases Musculoskeletal Diseases Neoplasms Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Radial Neuropathy Skin and Connective Tissue Diseases Tendinopathy Tendon Entrapment

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Health Sciences, FSM Training and Research Hospital, Istanbul

Istanbul, ataşehir, 34752, Turkey (Türkiye)

About this study

In the assessment of the first carpometacarpal (CMC) joint, the following ultrasonographic parameters will be evaluated: synovitis, presence of osteophytes, joint surface irregularity, and Doppler signal activity. Additionally, conventional hand radiographs of all participants will be reviewed to support the imaging findings.

For the evaluation of De Quervain's tenosynovitis, tendon sheath thickness, tendon cross-sectional area, and intratendinous Doppler activity will be measured. At the anatomical intersection zones of the first dorsal compartment, the presence of peritendinous fluid and associated Doppler activity will also be assessed to identify potential sites of friction or inflammation.

Assessment of the superficial radial nerve will include measurement of its cross-sectional area. A cross-sectional area exceeding one square millimeter will be considered indicative of possible neuropathy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • pain in dorsoradial wrist

Exclusion criteria

  • known rheumatological disease
  • history of forearm, wrist, hand fracture
  • history of forearm, wrist, hand operation
  • mental retardation
  • history of major trauma in forearm, wrist and hand
  • fibromyalgia

Treatment and study plan

Ultrasonographic examination

Other

ultrasonographic examination

Primary outcomes

  1. Odds Ratio of First Extensor Compartment Tendon Sheath Thickness Associated with De Quervain Disease

    Time frame: At the time of enrollment

    To quantify the association between increased tendon sheath thickness and clinical diagnosis of De Quervain tenosynovitis using logistic regression analysis.

  2. Odds Ratio of Synovial Hypertrophy in CMC Joint Associated with Carpometacarpal Arthritis

    Time frame: At the time of enrollment

    To assess the strength of association between ultrasonographic synovial hypertrophy and clinical diagnosis of carpometacarpal joint arthritis.

  3. Sensitivity of Ultrasonographic Parameters for Diagnosing Dorsoradial Wrist Pathologies

    Time frame: At the time of enrollment

    To assess the diagnostic sensitivity of individual ultrasonographic findings (e.g., tendon sheath thickness, synovial hypertrophy) for detecting De Quervain tenosynovitis and CMC arthritis.

  4. Specificity of Ultrasonographic Parameters for Diagnosing Dorsoradial Wrist Pathologies

    Time frame: At the time of enrollment

    To assess the diagnostic specificity of individual ultrasonographic findings for identifying De Quervain tenosynovitis and CMC arthritis.

Sponsors and collaborators

Lead sponsor

Fatih Sultan Mehmet Training and Research Hospital

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
May 20, 2025
Registry last updated
May 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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