The Comparison of Efficacy for Cervical Ripening in Labor Induction Between Titrated and Conventional Oral Misoprostol

The purpose of this study is to compare the efficacy for cervical ripening in labor induction between titrated and conventional oral misoprostol

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Key information

Conditions

Cervical Ripening Labor Induction

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Siriraj Hospital, Mahidol University

Bangkok, 10700, Thailand

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age 18 years old or more
singleton pregnancy at 37 weeks gestation or more
cephalic presentation
reassuring fetal heart rate pattern
admission for labor induction due to medical or obstetrical conditions
bishop score less than 6
giving consent and having signed the consent form for this study

Exclusion criteria

parity more than 3
estimated fetal weight more than 3,500 grams
non-reassuring fetal heart rate pattern
having contraindication for vaginal delivery
previous uterine scar
suspected abruptio placenta with non-reassuring fetal heart rate pattern
abnormal bleeding per vagina, except bloody show
PROM
having underlying cardiac, hepatic, or renal diseases
having history of allergy to misoprostol or prostaglandin analogues
cervical dilatation 3 centimeters or more
uterine contraction 3 times or more in 10 minute

Treatment and study plan

Misoprostol

Drug

misoprostol 50 micrograms oral every 4 hours until cervical dilatation 3 cm

Other names: cytotec

Primary outcomes

success rate of cervical ripening in labor induction

Time frame: 12 hours after intervention

Secondary outcomes

number of vaginal delivery

Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2009
Study completion: 2010
First posted: Apr 23, 2009
Registry last updated: Jul 14, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed