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NCT Number: NCT06762509

The Clinical Study of Botulinum Toxin Type A Injection in the Treatment of Wilson Disease

In order to expand the treatment of Wilson disease and improve the quality of life of patients with Wilson's disease, the clinical effect of botulinum toxin type A injection on Wilson's disease was discussed.

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Key information

Conditions

Wilson Disease Basal Ganglia Diseases Brain Diseases Brain Diseases, Metabolic Brain Diseases, Metabolic, Inborn Central Nervous System Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Digestive System Diseases Genetic Diseases, Inborn Hepatolenticular Degeneration Heredodegenerative Disorders, Nervous System Liver Diseases Metabolic Diseases Metabolism, Inborn Errors Metal Metabolism, Inborn Errors Movement Disorders Nervous System Diseases Neurodegenerative Diseases Nutritional and Metabolic Diseases

Age range

15 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, #117 Meishan Street, Shushan District Hefei 230037, China

Hefei, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

：1.Conform to the diagnosis of "2012 European Liver Study Guidelines for Diagnosis and Treatment of hepatolenticular degeneration". 2. Aged from 15 to 65 years.

Exclusion criteria

Non-Wilson's disease

Treatment and study plan

Botulinum Toxin Type A

Drug

Local injection of botulinum toxin type A was given at the time of enrollment

Primary outcomes

  1. Unified Dystonia Rating Scale(UDRS)

    Time frame: 4 weeks

    Unified Dystonia Rating Scale(UDRS),Higher scores mean a worse outcome.

  2. Unified Wilson's Disease Rating Scale(UWDRS)

    Time frame: 4 weeks

    Unified Wilson's Disease Rating Scale(UWDRS).Higher scores mean a worse outcome

  3. Numeric Rating Scales(NRS)

    Time frame: 4 weeks

    Numeric Rating Scales(NRS),Higher scores mean a worse outcome

  4. Activity of Daily Living Scale(ADL)

    Time frame: 4 weeks

    Activity of Daily Living Scale,Higher scores mean a better outcome.

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine

Other

Registry information

Acronym: WD

Important dates

Study start
2016
Primary completion
2023
Study completion
2024
First posted
Jan 7, 2025
Registry last updated
Jan 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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